PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study
SB Sirima, L Richert, A Chêne, AT Konate… - The Lancet Infectious …, 2020 - thelancet.com
Background PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …
The case for exploiting cross-species epitopes in malaria vaccine design
CJ Mitran, SK Yanow - Frontiers in Immunology, 2020 - frontiersin.org
The infection dynamics between different species of Plasmodium that infect the same human
host can both suppress and exacerbate disease. This could arise from inter-parasite …
host can both suppress and exacerbate disease. This could arise from inter-parasite …
Cross-species reactivity of antibodies against Plasmodium vivax blood-stage antigens to Plasmodium knowlesi
Malaria is caused by multiple different species of protozoan parasites, and interventions in
the pre-elimination phase can lead to drastic changes in the proportion of each species …
the pre-elimination phase can lead to drastic changes in the proportion of each species …
A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
Antibodies to cryptic epitopes in distant homologues underpin a mechanism of heterologous immunity between plasmodium vivax PvDBP and plasmodium falciparum …
CJ Mitran, A Mena, S Gnidehou, S Banman, E Arango… - MBio, 2019 - Am Soc Microbiol
Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to
evade host immunity. This poses a significant challenge for the host to develop broadly …
evade host immunity. This poses a significant challenge for the host to develop broadly …
Identification, Mapping, and Genetic Diversity of Novel Conserved Cross-Species Epitopes of RhopH2 in Plasmodium knowlesi With Plasmodium vivax
Malaria is a major public health concern, and any tangible intervention during the pre-
elimination phase can result in a significant reduction in infection rates. Recent studies have …
elimination phase can result in a significant reduction in infection rates. Recent studies have …
Identification of conserved cross-species B-cell linear epitopes in human malaria: A subtractive proteomics and immuno-informatics approach targeting merozoite …
Human malaria, caused by five Plasmodium species (P. falciparum, P. vivax, P. malariae, P.
ovale, and P. knowlesi), remains a significant global health burden. While most interventions …
ovale, and P. knowlesi), remains a significant global health burden. While most interventions …
Acquisition of antibodies to Plasmodium falciparum and Plasmodium vivax antigens in pregnant women living in a low malaria transmission area of Brazil
MW Kassa, W Hasang, A Barateiro, T Damelang… - Malaria Journal, 2022 - Springer
Background Pregnant women have increased susceptibility to Plasmodium falciparum
malaria and acquire protective antibodies over successive pregnancies. Most studies that …
malaria and acquire protective antibodies over successive pregnancies. Most studies that …
[HTML][HTML] Cross-reactivity of rPvs48/45, a recombinant Plasmodium vivax protein, with sera from Plasmodium falciparum endemic areas of Africa
S Balam, K Miura, I Ayadi, D Konaté, NC Incandela… - bioRxiv, 2024 - ncbi.nlm.nih.gov
Background: Ps48/45, a Plasmodium gametocyte surface protein, is a promising candidate
for malaria transmission-blocking (TB) vaccine. Due to its relevance for a multispecies …
for malaria transmission-blocking (TB) vaccine. Due to its relevance for a multispecies …
Overview of Epidemiology of Malaria Associated with Pregnancy in Northwestern Colombia, 1985-2020
J Carmona-Fonseca… - … (E-ISSN: 2581 …, 2021 - medical …
Background: Knowledge about malaria associated with pregnancy (MAP) is scarce in Latin
America and Colombia. Methodology: This paper presents an overview of studies captained …
America and Colombia. Methodology: This paper presents an overview of studies captained …