Host–microbiota interactions in inflammatory bowel disease

R Caruso, BC Lo, G Núñez - Nature Reviews Immunology, 2020 - nature.com
The mammalian intestine is colonized by trillions of microorganisms that have co-evolved
with the host in a symbiotic relationship. The presence of large numbers of symbionts near …

The human gut microbiome–a potential controller of wellness and disease

ZY Kho, SK Lal - Frontiers in microbiology, 2018 - frontiersin.org
Interest toward the human microbiome, particularly gut microbiome has flourished in recent
decades owing to the rapidly advancing sequence-based screening and humanized …

Human memory T cells: generation, compartmentalization and homeostasis

DL Farber, NA Yudanin, NP Restifo - Nature Reviews Immunology, 2014 - nature.com
Memory T cells constitute the most abundant lymphocyte population in the body for the
majority of a person's lifetime; however, our understanding of memory T cell generation …

Therapeutic faecal microbiota transplantation controls intestinal inflammation through IL10 secretion by immune cells

C Burrello, F Garavaglia, FM Cribiù, G Ercoli… - Nature …, 2018 - nature.com
Alteration of the gut microbiota has been associated with different gastrointestinal disorders.
Normobiosis restoration by faecal microbiota transplantation (FMT) is considered a …

Circulating and tissue-resident CD4+ T cells with reactivity to intestinal microbiota are abundant in healthy individuals and function is altered during inflammation

AN Hegazy, NR West, MJT Stubbington, E Wendt… - Gastroenterology, 2017 - Elsevier
Background & Aims Interactions between commensal microbes and the immune system are
tightly regulated and maintain intestinal homeostasis, but little is known about these …

Intestinal epithelial HDAC3 and MHC class II coordinate microbiota-specific immunity

EM Eshleman, TY Shao, V Woo, T Rice… - The Journal of …, 2023 - Am Soc Clin Investig
Aberrant immune responses to resident microbes promote inflammatory bowel disease and
other chronic inflammatory conditions. However, how microbiota-specific immunity is …

[HTML][HTML] Ecological and evolutionary forces shaping microbial diversity in the human intestine

RE Ley, DA Peterson, JI Gordon - Cell, 2006 - cell.com
The human gut is populated with as many as 100 trillion cells, whose collective genome, the
microbiome, is a reflection of evolutionary selection pressures acting at the level of the host …

Polysaccharide utilization by gut bacteria: potential for new insights from genomic analysis

HJ Flint, EA Bayer, MT Rincon, R Lamed… - Nature Reviews …, 2008 - nature.com
The microbiota of the mammalian intestine depend largely on dietary polysaccharides as
energy sources. Most of these polymers are not degradable by the host, but herbivores can …

The immunology of mucosal models of inflammation

W Strober, IJ Fuss, RS Blumberg - Annual review of …, 2002 - annualreviews.org
In recent years the status of the inflammatory bowel diseases (IBDs) as canonical
autoimmune diseases has risen steadily with the recognition that these diseases are, at their …

Dysbiosis in inflammatory bowel disease

CP Tamboli, C Neut, P Desreumaux, JF Colombel - Gut, 2004 - gut.bmj.com
Abundant data have incriminated intestinal bacteria in the initiation and amplification stages
of inflammatory bowel diseases. However, the precise role of intestinal bacteria remains …