T cell antigen receptor recognition of antigen-presenting molecules
The Major Histocompatibility Complex (MHC) locus encodes classical MHC class I and MHC
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
class II molecules and nonclassical MHC-I molecules. The architecture of these molecules is …
TCR recognition of peptide–MHC-I: Rule makers and breakers
T cells are a critical part of the adaptive immune system that are able to distinguish between
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
healthy and unhealthy cells. Upon recognition of protein fragments (peptides), activated T …
NetTCR-2.0 enables accurate prediction of TCR-peptide binding by using paired TCRα and β sequence data
A Montemurro, V Schuster, HR Povlsen… - Communications …, 2021 - nature.com
Prediction of T-cell receptor (TCR) interactions with MHC-peptide complexes remains highly
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …
challenging. This challenge is primarily due to three dominant factors: data accuracy, data …
Understanding the drivers of MHC restriction of T cell receptors
T cell discrimination of self and non-self is predicated on αβ T cell receptor (TCR) co-
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
recognition of peptides presented by MHC molecules. Over the past 20 years, structurally …
Why must T cells be cross-reactive?
AK Sewell - Nature Reviews Immunology, 2012 - nature.com
Clonal selection theory proposed that individual T cells are specific for a single peptide–
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
MHC antigen. However, the repertoire of αβ T cell receptors (TCRs) is dwarfed by the vast …
On TCR binding predictors failing to generalize to unseen peptides
Several recent studies investigate TCR-peptide/-pMHC binding prediction using machine
learning or deep learning approaches. Many of these methods achieve impressive results …
learning or deep learning approaches. Many of these methods achieve impressive results …
Canonical T cell receptor docking on peptide–MHC is essential for T cell signaling
INTRODUCTION T cell receptor (TCR) recognition of peptide–major histocompatibility
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
complexes (pMHCs) is one of the most diverse receptor–ligand interactions in biology …
Decision checkpoints in the thymus
AC Carpenter, R Bosselut - Nature immunology, 2010 - nature.com
The development of T cells in the thymus involves several differentiation and proliferation
events, during which hematopoietic precursors give rise to T cells ready to respond to …
events, during which hematopoietic precursors give rise to T cells ready to respond to …
Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling
KW Wucherpfennig, E Gagnon… - Cold Spring …, 2010 - cshperspectives.cshlp.org
The T-cell receptor (TCR)-CD3 complex serves as a central paradigm for general principles
of receptor assembly, ligand recognition, and signaling in the immune system. There is no …
of receptor assembly, ligand recognition, and signaling in the immune system. There is no …
T cell receptor signaling is limited by docking geometry to peptide-major histocompatibility complex
T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …
essential to adaptive immunity, but it is unknown whether TCR signaling responses are …