Diffuse midline gliomas (DMG) are a highly aggressive and universally fatal subgroup of
pediatric tumors responsible for the majority of childhood brain tumor deaths. Median overall …

Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children.
DMG typically presents with variable neurologic symptoms between ages 3 and 10 …

Hematologic malignancies are a large and heterogeneous group of neoplasms
characterized by complex pathogenetic mechanisms. The abnormal regulation of epigenetic …

Colorectal cancer (CRC) is one of the most common cancers worldwide. Nowadays, owing
to the complex mechanism of tumorigenesis, simultaneous inhibition of multiple targets is an …

Diffuse midline glioma (DMG), including tumors diagnosed in the brainstem (diffuse intrinsic
pontine glioma-DIPG), is the primary cause of brain tumor-related death in pediatric patients …

Diffuse intrinsic pontine glioma (DIPG) is a childhood malignancy of the brainstem with a
dismal prognosis. Despite recent advances in its understanding at the molecular level, the …

Simple Summary Pediatric high-grade gliomas (pHGGs) are the leading cause of mortality in
pediatric neuro-oncology, due in great part to treatment resistance driven by complex DNA …

Diffuse intrinsic pontine gliomas (DIPGs) are deadly pediatric brain tumors, non-resectable
due to brainstem localization and diffusive growth. Over 80% of DIPGs harbor a mutation in …

Abstract Purpose of Review Diffuse midline gliomas (DMGs) generally carry a poor
prognosis, occur during childhood, and involve midline structures of the central nervous …

Diffuse midline glioma with H3K27 M alteration is a primary malignant tumor located along
the linear structure of the brain, predominantly manifesting in children and adolescents. The …