The roles of histone variants in fine-tuning chromatin organization and function
S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …
post-translational modification and chromatin remodelling complexes, histone variants …
Dynamics of the epigenetic landscape during the maternal-to-zygotic transition
MA Eckersley-Maslin, C Alda-Catalinas… - … Reviews Molecular Cell …, 2018 - nature.com
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …
Epigenetic regulator function through mouse gastrulation
S Grosswendt, H Kretzmer, ZD Smith, AS Kumar… - Nature, 2020 - nature.com
During ontogeny, proliferating cells become restricted in their fate through the combined
action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which …
action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which …
LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo
After fertilization, to initiate development, gametes are reprogramed to become totipotent.
Approximately half of the mammalian genome consists of repetitive elements, including …
Approximately half of the mammalian genome consists of repetitive elements, including …
Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq)
DNA methylation (DNAme) is an important epigenetic mark in diverse species. Our current
understanding of DNAme is based on measurements from bulk cell samples, which …
understanding of DNAme is based on measurements from bulk cell samples, which …
Establishment and functions of DNA methylation in the germline
KR Stewart, L Veselovska, G Kelsey - Epigenomics, 2016 - Taylor & Francis
Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …
Phosphorylation of histone H3. 3 at serine 31 promotes p300 activity and enhancer acetylation
The histone variant H3. 3 is enriched at enhancers and active genes, as well as repeat
regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs) …
regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs) …
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes
CW Hanna, A Taudt, J Huang, L Gahurova… - Nature structural & …, 2018 - nature.com
Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …
METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice
H Mu, T Zhang, Y Yang, D Zhang, J Gao, J Li… - Cell Death & …, 2021 - nature.com
Proper follicle development is very important for the production of mature oocytes, which is
essential for the maintenance of female fertility. This complex biological process requires …
essential for the maintenance of female fertility. This complex biological process requires …
The role and mechanisms of DNA methylation in the oocyte
G Sendžikaitė, G Kelsey - Essays in Biochemistry, 2019 - portlandpress.com
Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …
next generation and influence gene expression; this occurs naturally in the case of imprinted …