The roles of histone variants in fine-tuning chromatin organization and function

S Martire, LA Banaszynski - Nature reviews Molecular cell biology, 2020 - nature.com
Histones serve to both package and organize DNA within the nucleus. In addition to histone
post-translational modification and chromatin remodelling complexes, histone variants …

Dynamics of the epigenetic landscape during the maternal-to-zygotic transition

MA Eckersley-Maslin, C Alda-Catalinas… - … Reviews Molecular Cell …, 2018 - nature.com
A remarkable epigenetic remodelling process occurs shortly after fertilization, which restores
totipotency to the zygote. This involves global DNA demethylation, chromatin remodelling …

Epigenetic regulator function through mouse gastrulation

S Grosswendt, H Kretzmer, ZD Smith, AS Kumar… - Nature, 2020 - nature.com
During ontogeny, proliferating cells become restricted in their fate through the combined
action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which …

LINE-1 activation after fertilization regulates global chromatin accessibility in the early mouse embryo

JW Jachowicz, X Bing, J Pontabry, A Bošković… - Nature …, 2017 - nature.com
After fertilization, to initiate development, gametes are reprogramed to become totipotent.
Approximately half of the mammalian genome consists of repetitive elements, including …

Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq)

SJ Clark, SA Smallwood, HJ Lee, F Krueger, W Reik… - Nature protocols, 2017 - nature.com
DNA methylation (DNAme) is an important epigenetic mark in diverse species. Our current
understanding of DNAme is based on measurements from bulk cell samples, which …

Establishment and functions of DNA methylation in the germline

KR Stewart, L Veselovska, G Kelsey - Epigenomics, 2016 - Taylor & Francis
Epigenetic modifications established during gametogenesis regulate transcription and other
nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal …

Phosphorylation of histone H3. 3 at serine 31 promotes p300 activity and enhancer acetylation

S Martire, AA Gogate, A Whitmill, A Tafessu, J Nguyen… - Nature …, 2019 - nature.com
The histone variant H3. 3 is enriched at enhancers and active genes, as well as repeat
regions such as telomeres and retroelements, in mouse embryonic stem cells (mESCs) …

MLL2 conveys transcription-independent H3K4 trimethylation in oocytes

CW Hanna, A Taudt, J Huang, L Gahurova… - Nature structural & …, 2018 - nature.com
Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …

METTL3-mediated mRNA N6-methyladenosine is required for oocyte and follicle development in mice

H Mu, T Zhang, Y Yang, D Zhang, J Gao, J Li… - Cell Death & …, 2021 - nature.com
Proper follicle development is very important for the production of mature oocytes, which is
essential for the maintenance of female fertility. This complex biological process requires …

The role and mechanisms of DNA methylation in the oocyte

G Sendžikaitė, G Kelsey - Essays in Biochemistry, 2019 - portlandpress.com
Epigenetic information in the mammalian oocyte has the potential to be transmitted to the
next generation and influence gene expression; this occurs naturally in the case of imprinted …