Primary aldosteronism is the most common single cause of hypertension and is potentially
curable when only one adrenal gland is the culprit. The importance of primary aldosteronism …

Genomic variants affecting pre-messenger RNA splicing and its regulation are known to
underlie many rare genetic diseases. However, common workflows for genetic diagnosis …

Objective The human adrenal cortex comprises three functionally and structurally distinct
layers that produce layer-specific steroid hormones. With aging, the human adrenal cortex …

Adrenocortical carcinoma (ACC) is a rare yet devastating tumour of the adrenal gland with a
molecular pathology that remains incompletely understood. To gain novel insights into the …

The steroid hormone aldosterone, produced by the zona glomerulosa (zG) of the adrenal
gland, is a master regulator of plasma electrolytes and blood pressure. While aldosterone …

We read with great interest the article by Amano et al, which addresses single-exon 2
deletions of ZNRF3 as a novel contributor to adrenal hypoplasia (1). The advent of …