Multicomponent reactions for the synthesis of bioactive compounds: A review

CS Graebin, FV Ribeiro, KR Rogério… - Current Organic …, 2019 - ingentaconnect.com
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions …

Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review

LHS Matos, FT Masson, LA Simeoni… - European journal of …, 2018 - Elsevier
Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …

1, 2, 4-Triazole and 1, 3, 4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial …

SS Thakkar, P Thakor, H Doshi, A Ray - Bioorganic & Medicinal Chemistry, 2017 - Elsevier
Triazole and 1, 3, 4-oxadiazole analogues are of interest due to their potential activity
against microbial and malarial infections. In search of suitable antimicrobial and antimalarial …

A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …

S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …

New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies

DH Dawood, MM Sayed, STK Tohamy, ES Nossier - ACS omega, 2023 - ACS Publications
The antibiotic resistance problems constitute a considerable threat to human health
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …

Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and …

SS Thakkar, P Thakor, A Ray, H Doshi… - Bioorganic & Medicinal …, 2017 - Elsevier
Benzothiazole analogues are of interest due to their potential activity against malarial and
microbial infections. In search of suitable antimicrobial and antimalarial agents, we report …

A review on anticancer activities of thiophene and its analogs

R Mishra, N Kumar, I Mishra… - Mini Reviews in …, 2020 - ingentaconnect.com
Cancer is the world's second-largest cause of mortality and one of the biggest global health
concerns. The prevalence and mortality rates of cancer remain high despite significant …

Thiophene‐containing compounds with antimicrobial activity

G Roman - Archiv der Pharmazie, 2022 - Wiley Online Library
Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …

Thiophene scaffold as prospective antimicrobial agent: A Review

R Mishra, N Sachan, N Kumar, I Mishra… - Journal of …, 2018 - Wiley Online Library
Thiophene has emerged as a potent scaffold that has pulled the keen interest of the
researchers because of its considerable diversity in biological activities. The versatility of the …

[HTML][HTML] Magical bullets from an indigenous Indian medicinal plant Tinospora cordifolia: an in silico approach for the antidote of SARS-CoV-2

SS Thakkar, F Shelat, P Thakor - Egyptian Journal of Petroleum, 2021 - Elsevier
Abstract World Health Organization declared COVID-19 as a global pandemic. Till now, a
diverse array of drugs failed to combat. There is an immense need of novel lead molecules …