Multicomponent reactions for the synthesis of bioactive compounds: A review
CS Graebin, FV Ribeiro, KR Rogério… - Current Organic …, 2019 - ingentaconnect.com
Multicomponent reactions (MCRs) are composed of three or more reagents in which the final
product has all or most of the carbon atoms from its starting materials. These reactions …
product has all or most of the carbon atoms from its starting materials. These reactions …
Biological activity of dihydropyrimidinone (DHPM) derivatives: A systematic review
LHS Matos, FT Masson, LA Simeoni… - European journal of …, 2018 - Elsevier
Dihydropyrimidinones are heterocycles with a pyrimidine moiety in the ring nucleus, which,
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …
in recent decades, have aroused interest in medicinal chemistry due to alleged versatile …
1, 2, 4-Triazole and 1, 3, 4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial …
Triazole and 1, 3, 4-oxadiazole analogues are of interest due to their potential activity
against microbial and malarial infections. In search of suitable antimicrobial and antimalarial …
against microbial and malarial infections. In search of suitable antimicrobial and antimalarial …
A century-old one-pot multicomponent Biginelli reaction products still finds a niche in drug discoveries: Synthesis, mechanistic studies and diverse biological activities …
S Faizan, TF Roohi, RM Raju, Y Sivamani… - Journal of Molecular …, 2023 - Elsevier
One of the largest classes of organic molecules are dihydropyrimidines and its derivatives.
They are widely used in a variety of pharmacological and industrial applications. Their …
They are widely used in a variety of pharmacological and industrial applications. Their …
New Thiophenyl-pyrazolyl-thiazole Hybrids as DHFR Inhibitors: Design, Synthesis, Antimicrobial Evaluation, Molecular Modeling, and Biodistribution Studies
DH Dawood, MM Sayed, STK Tohamy, ES Nossier - ACS omega, 2023 - ACS Publications
The antibiotic resistance problems constitute a considerable threat to human health
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …
worldwide; thus, the discovery of new antimicrobial candidates to conquer this issue is an …
Benzothiazole analogues: Synthesis, characterization, MO calculations with PM6 and DFT, in silico studies and in vitro antimalarial as DHFR inhibitors and …
Benzothiazole analogues are of interest due to their potential activity against malarial and
microbial infections. In search of suitable antimicrobial and antimalarial agents, we report …
microbial infections. In search of suitable antimicrobial and antimalarial agents, we report …
A review on anticancer activities of thiophene and its analogs
Cancer is the world's second-largest cause of mortality and one of the biggest global health
concerns. The prevalence and mortality rates of cancer remain high despite significant …
concerns. The prevalence and mortality rates of cancer remain high despite significant …
Thiophene‐containing compounds with antimicrobial activity
G Roman - Archiv der Pharmazie, 2022 - Wiley Online Library
Thiophene, as a member of the group of five‐membered heterocycles containing one
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …
heteroatom, is one of the simplest heterocyclic systems. Many synthetic strategies allow the …
Thiophene scaffold as prospective antimicrobial agent: A Review
Thiophene has emerged as a potent scaffold that has pulled the keen interest of the
researchers because of its considerable diversity in biological activities. The versatility of the …
researchers because of its considerable diversity in biological activities. The versatility of the …
[HTML][HTML] Magical bullets from an indigenous Indian medicinal plant Tinospora cordifolia: an in silico approach for the antidote of SARS-CoV-2
SS Thakkar, F Shelat, P Thakor - Egyptian Journal of Petroleum, 2021 - Elsevier
Abstract World Health Organization declared COVID-19 as a global pandemic. Till now, a
diverse array of drugs failed to combat. There is an immense need of novel lead molecules …
diverse array of drugs failed to combat. There is an immense need of novel lead molecules …