From the beginning, induced pluripotent stem cell (iPSC) technology was touted as a path to
improve our understanding of disease biology and enable drug discovery. Advances in …

In most mouse models of disease, the outward manifestation of a disorder can be measured
easily, can be assessed with a trivial test such as hind limb clasping, or can even be …

Human induced pluripotent stem cell derived brain organoids have shown great potential for
studies of human brain development and neurological disorders. However, quantifying the …

We report a new hybrid integration scheme that offers for the first time a nanowire-on-lead
approach, which enables independent electrical addressability, is scalable, and has …

Impaired neuronal network function is a hallmark of neurodevelopmental and
neurodegenerative disorders such as autism, schizophrenia, and Alzheimer's disease and is …

The maturation and functional characteristics of human induced pluripotent stem cell
(hiPSC)-cortical neurons has not been fully documented. This study developed a phenotypic …

Brain-on-a-chip (BoC) concepts should consider three-dimensional (3D) scaffolds to mimic
the 3D nature of the human brain not accessible by conventional planar cell culturing …

Cutaneous innervation is increasingly recognized as a major element of skin
physiopathology through the neurogenic inflammation driven by neuropeptides that are …

The chronic pain syndrome inherited erythromelalgia (IEM) is attributed to mutations in the
voltage-gated sodium channel (NaV) 1.7. Still, recent studies targeting NaV1. 7 in clinical …

Familial Alzheimer's disease (FAD) is clearly related with the accumulation of amyloid-beta
(Aβ) and its deleterious effect on mitochondrial function is well established. Anomalies in …