Function and evolution of vertebrate globins

T Burmester, T Hankeln - Acta Physiologica, 2014 - Wiley Online Library
Globins are haem‐proteins that bind O2 and thus play an important role in the animal's
respiration and oxidative energy production. However, globins may also have other …

No oxygen? No problem! Intrinsic brain tolerance to hypoxia in vertebrates

J Larson, KL Drew, LP Folkow… - Journal of …, 2014 - journals.biologists.com
Many vertebrates are challenged by either chronic or acute episodes of low oxygen
availability in their natural environments. Brain function is especially vulnerable to the effects …

Reactive glial cells: increased stiffness correlates with increased intermediate filament expression

YB Lu, I Iandiev, M Hollborn, N Körber… - The FASEB …, 2011 - Wiley Online Library
Increased stiffness of reactive glial cells may impede neurite growth and contribute to the
poor regenerative capabilities of the mammalian central nervous system. We induced …

Neuroglobin: From structure to function in health and disease

P Ascenzi, A di Masi, L Leboffe, M Fiocchetti… - Molecular aspects of …, 2016 - Elsevier
In 2000, the third member of the globin family was discovered in human and mouse brain
and named neuroglobin (Ngb). Ngb is a monomeric 3/3 globin structurally similar to …

Neuroglobin, cytoglobin, and myoglobin contribute to hypoxia adaptation of the subterranean mole rat Spalax

A Avivi, F Gerlach, A Joel, S Reuss… - Proceedings of the …, 2010 - National Acad Sciences
The subterranean mole rat Spalax is an excellent model for studying adaptation of a
mammal toward chronic environmental hypoxia. Neuroglobin (Ngb) and cytoglobin (Cygb) …

A review of the multi-level adaptations for maximizing aerobic dive duration in marine mammals: from biochemistry to behavior

RW Davis - Journal of Comparative Physiology B, 2014 - Springer
Marine mammals exhibit multi-level adaptations, from cellular biochemistry to behavior, that
maximize aerobic dive duration. A dive response during aerobic dives enables the efficient …

Neuroglobin protects astroglial cells from hydrogen peroxide‐induced oxidative stress and apoptotic cell death

F Amri, I Ghouili, M Amri, A Carrier… - Journal of …, 2017 - Wiley Online Library
Oxidative stress, resulting from accumulation of reactive oxygen species, plays a critical role
in astroglial cell death occurring in diverse neuropathological conditions. Numerous studies …

17β‐Oestradiol anti‐inflammatory effects in primary astrocytes require oestrogen receptor β‐mediated neuroglobin up‐regulation

E De Marinis, E Acaz‐Fonseca… - Journal of …, 2013 - Wiley Online Library
Neuroglobin (Ngb), so named after its initial discovery in brain neurones, has received great
attention as a result of its neuroprotective effects both in vitro and in vivo. Recently, we …

Breath-hold diving–the physiology of diving deep and returning

A Patrician, Ž Dujić, B Spajić, I Drviš… - Frontiers in …, 2021 - frontiersin.org
Breath-hold diving involves highly integrative physiology and extreme responses to both
exercise and asphyxia during progressive elevations in hydrostatic pressure. With …

Old proteins–new locations: myoglobin, haemoglobin, neuroglobin and cytoglobin in solid tumours and cancer cells

TA Gorr, D Wichmann, C Pilarsky… - Acta …, 2011 - Wiley Online Library
Aim: The unexpected identification of myoglobin (MB) in breast cancer prompted us to
evaluate the clinico‐pathological value of MB, haemoglobin (HB) and cytoglobin (CYGB) in …