Progress in the Chemistry of Tetrahydroquinolines
I Muthukrishnan, V Sridharan, JC Menendez - Chemical reviews, 2019 - ACS Publications
Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …
widespread in nature and present in a broad variety of pharmacologically active …
[HTML][HTML] G protein–coupled estrogen receptor GPER: molecular pharmacology and therapeutic applications
JB Arterburn, ER Prossnitz - Annual review of pharmacology …, 2023 - annualreviews.org
The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …
Advances in the chemistry of tetrahydroquinolines
V Sridharan, PA Suryavanshi, JC Menendez - Chemical reviews, 2011 - ACS Publications
1.1. General Heterocyclic compounds, especially nitrogen heterocycles, are the most
important class of compounds in the pharmaceutical and agrochemical industries, with …
important class of compounds in the pharmaceutical and agrochemical industries, with …
Identification of a GPER/GPR30 antagonist with improved estrogen receptor counterselectivity
GPER/GPR30 is a seven-transmembrane G protein-coupled estrogen receptor that
regulates many aspects of mammalian biology and physiology. We have previously …
regulates many aspects of mammalian biology and physiology. We have previously …
International union of basic and clinical pharmacology. XCVII. G protein–coupled estrogen receptor and its pharmacologic modulators
ER Prossnitz, JB Arterburn - Pharmacological reviews, 2015 - ASPET
Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …
[HTML][HTML] G protein-coupled estrogen receptor protects from atherosclerosis
MR Meyer, NC Fredette, TA Howard, C Hu… - Scientific reports, 2014 - nature.com
Coronary atherosclerosis and myocardial infarction in postmenopausal women have been
linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts …
linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts …
Role of GPER in estrogen-dependent nitric oxide formation and vasodilation
Estrogens are potent regulators of vasomotor tone, yet underlying receptor-and ligand-
specific signaling pathways remain poorly characterized. The primary physiological …
specific signaling pathways remain poorly characterized. The primary physiological …
[HTML][HTML] Sex steroids regulate skin pigmentation through nonclassical membrane-bound receptors
The association between pregnancy and altered cutaneous pigmentation has been
documented for over two millennia, suggesting that sex hormones play a role in regulating …
documented for over two millennia, suggesting that sex hormones play a role in regulating …
Preclinical efficacy of the GPER-selective agonist G-1 in mouse models of obesity and diabetes
Human obesity has become a global health epidemic, with few safe and effective
pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in …
pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in …
Enantioselective synthesis of hexahydrofuro [3, 2-c] quinolines through a multicatalytic and multicomponent process. A new “aromatic sandwich” model for BINOL …
J Calleja, AB González-Pérez, ÁR de Lera… - Chemical …, 2014 - pubs.rsc.org
A new and straightforward metal–organo orthogonal-relay catalytic asymmetric reaction for
the enantioselective synthesis of hexahydrofuro [3, 2-c] quinolines is reported. The process …
the enantioselective synthesis of hexahydrofuro [3, 2-c] quinolines is reported. The process …