Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, being
widespread in nature and present in a broad variety of pharmacologically active …

The actions of estrogens and related estrogenic molecules are complex and multifaceted in
both sexes. A wide array of natural, synthetic, and therapeutic molecules target pathways …

1.1. General Heterocyclic compounds, especially nitrogen heterocycles, are the most
important class of compounds in the pharmaceutical and agrochemical industries, with …

GPER/GPR30 is a seven-transmembrane G protein-coupled estrogen receptor that
regulates many aspects of mammalian biology and physiology. We have previously …

Estrogens are critical mediators of multiple and diverse physiologic effects throughout the
body in both sexes, including the reproductive, cardiovascular, endocrine, nervous, and …

Coronary atherosclerosis and myocardial infarction in postmenopausal women have been
linked to inflammation and reduced nitric oxide (NO) formation. Natural estrogen exerts …

Estrogens are potent regulators of vasomotor tone, yet underlying receptor-and ligand-
specific signaling pathways remain poorly characterized. The primary physiological …

The association between pregnancy and altered cutaneous pigmentation has been
documented for over two millennia, suggesting that sex hormones play a role in regulating …

Human obesity has become a global health epidemic, with few safe and effective
pharmacological therapies currently available. The systemic loss of ovarian estradiol (E2) in …

A new and straightforward metal–organo orthogonal-relay catalytic asymmetric reaction for
the enantioselective synthesis of hexahydrofuro [3, 2-c] quinolines is reported. The process …