The rising global prevalence of obesity, metabolic syndrome, and type 2 diabetes has driven
a sharp increase in non-alcoholic fatty liver disease (NAFLD), characterized by excessive fat …

Cells have a constant turnover of proteins that recycle most amino acids over time. Net loss
is mainly due to amino acid oxidation. Homeostasis is achieved through exchange of …

It has been more than a dozen years since FGF21 burst on the metabolism field in a paper
showing that its pharmacologic administration caused weight loss and improved insulin …

Since its identification in 2000, the interest of scientists in the hepatokine fibroblast growth
factor (FGF) 21 has tremendously grown, and still remains high, due to a wealth of very …

Members of the fibroblast growth factor (FGF) family play pleiotropic roles in cellular and
metabolic homeostasis. During evolution, the ancestor FGF expands into multiple members …

Animals that consume fermenting fruit and nectar are at risk of exposure to ethanol and the
detrimental effects of inebriation. In this report, we show that the hormone FGF21, which is …

The contribution of adipose-derived FGF21 to energy homeostasis is unclear. Here we show
that browning of inguinal white adipose tissue (iWAT) by β-adrenergic agonists requires …

The fibroblast growth factor (FGF) family is composed of 18 secreted signaling proteins
consisting of canonical FGFs and endocrine FGFs that activate four receptor tyrosine …

The worldwide epidemics of obesity, hypertriglyceridemia, dyslipidaemia, type 2 diabetes,
and metabolic dysfunction-associated steatotic liver disease (MASLD)/metabolic dysfunction …

Fibroblast growth factor 21 (FGF21) controls metabolic organ homeostasis and
eating/drinking behavior via FGF receptor 1/Klothoβ (FGFR1/KLB) complexes expressed in …