Endometriosis is a prevalent gynecological condition associated with pelvic pain and
infertility. Despite more than a century of research, the etiology of endometriosis still eludes …

This review discusses mechanisms by which progesterone receptors (PR) regulate
transcription. We examine available data in different species and tissues regarding:(1) …

Studies indicate that estrogen receptor (ER) α mediates breast cancer-promoting effects of
estrogens. The role of ERβ in breast cancer is unknown. Elucidating the role of ERβ in the …

This paper reviews work on progesterone and the progesterone receptor (PR) in the mouse
mammary gland that has been used extensively as an experimental model. Studies have led …

Progesterone is a critical regulator of normal female reproductive function, with diverse
tissue-specific effects in the human. The effects of progesterone are mediated by its nuclear …

The uterine endometrium is exquisitely sensitive to steroid hormones that act through well-
described nuclear receptors. Estrogen drives epithelial proliferation, and progesterone …

Progesterone is an ovarian steroid hormone that is essential for normal breast development
during puberty and in preparation for lactation and breastfeeding. The actions of …

The utility and safety of postmenopausal hormone replacement therapy has recently been
put into question by large clinical trials. Their outcome has been extensively commented …

Progesterone receptors (PRs) are prognostic markers in breast cancers irrespective of the
patient's progestational status. However, there are two PR isoforms, PR-A and PR-B, that are …

Human progesterone receptors (PR) rapidly activate cytosolic signaling pathways, in
addition to their classical function as ligand-activated transcription factors. Using ER+/PR-B+ …