Phosphorylated tau in Alzheimer's disease and other tauopathies

P Rawat, U Sehar, J Bisht, A Selman… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …

Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies

S Patel, A Rauf, H Khan, T Abu-Izneid - Biomedicine & Pharmacotherapy, 2017 - Elsevier
Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …

Role of tau protein in Alzheimer's disease: The prime pathological player

S Muralidar, SV Ambi, S Sekaran, D Thirumalai… - International journal of …, 2020 - Elsevier
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …

Dietary anti-aging polyphenols and potential mechanisms

J Luo, H Si, Z Jia, D Liu - Antioxidants, 2021 - mdpi.com
For years, the consumption of a diet rich in fruits and vegetables has been considered
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …

c-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer's disease

R Yarza, S Vela, M Solas, MJ Ramirez - Frontiers in pharmacology, 2016 - frontiersin.org
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …

Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia

M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …

Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents

M Jouanne, S Rault, AS Voisin-Chiret - European journal of medicinal …, 2017 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological
dysfunctions are involved. Among them, two main types of lesions were discovered and …

[PDF][PDF] Tau does not stabilize axonal microtubules but rather enables them to have long labile domains

L Qiang, X Sun, TO Austin, H Muralidharan, DC Jean… - Current Biology, 2018 - cell.com
It is widely believed that tau stabilizes microtubules in the axon [1–3] and, hence, that
disease-induced loss of tau from axonal microtubules leads to their destabilization [3–5]. An …

Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and Tau aggregates in Alzheimer's disease

H Rai, S Gupta, S Kumar, J Yang… - Journal of Medicinal …, 2022 - ACS Publications
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …

[HTML][HTML] Implications of GABAergic neurotransmission in Alzheimer's disease

Y Li, H Sun, Z Chen, H Xu, G Bu… - Frontiers in aging …, 2016 - frontiersin.org
Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …