Phosphorylated tau in Alzheimer's disease and other tauopathies
Alzheimer's disease (AD) is the leading cause of dementia in elderly people. Amyloid beta
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
(Aβ) deposits and neurofibrillary tangles are the major pathological features in an …
Renin-angiotensin-aldosterone (RAAS): The ubiquitous system for homeostasis and pathologies
Renin-angiotensin-aldosterone system (RAAS) is a vital system of human body, as it
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …
maintains plasma sodium concentration, arterial blood pressure and extracellular volume …
Role of tau protein in Alzheimer's disease: The prime pathological player
Alzheimer's disease (AD) is a prevalently found tauopathy characterized by memory loss
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
and cognitive insufficiency. AD is an age-related neurodegenerative disease with two major …
Dietary anti-aging polyphenols and potential mechanisms
For years, the consumption of a diet rich in fruits and vegetables has been considered
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …
healthy, increasing longevity, and decreasing morbidities. With the assistance of basic …
c-Jun N-terminal kinase (JNK) signaling as a therapeutic target for Alzheimer's disease
R Yarza, S Vela, M Solas, MJ Ramirez - Frontiers in pharmacology, 2016 - frontiersin.org
c-Jun N-terminal kinases (JNKs) are a family of protein kinases that play a central role in
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …
stress signaling pathways implicated in gene expression, neuronal plasticity, regeneration …
Alzheimer's disease pathogenesis: Role of autophagy and mitophagy focusing in microglia
M Eshraghi, A Adlimoghaddam… - International Journal of …, 2021 - mdpi.com
Alzheimer's disease (AD) is a debilitating neurological disorder, and currently, there is no
cure for it. Several pathologic alterations have been described in the brain of AD patients …
cure for it. Several pathologic alterations have been described in the brain of AD patients …
Tau protein aggregation in Alzheimer's disease: An attractive target for the development of novel therapeutic agents
M Jouanne, S Rault, AS Voisin-Chiret - European journal of medicinal …, 2017 - Elsevier
Alzheimer's Disease (AD) is a neurodegenerative brain disorder in which many biological
dysfunctions are involved. Among them, two main types of lesions were discovered and …
dysfunctions are involved. Among them, two main types of lesions were discovered and …
[PDF][PDF] Tau does not stabilize axonal microtubules but rather enables them to have long labile domains
It is widely believed that tau stabilizes microtubules in the axon [1–3] and, hence, that
disease-induced loss of tau from axonal microtubules leads to their destabilization [3–5]. An …
disease-induced loss of tau from axonal microtubules leads to their destabilization [3–5]. An …
Near-infrared fluorescent probes as imaging and theranostic modalities for amyloid-beta and Tau aggregates in Alzheimer's disease
A person suspected of having Alzheimer's disease (AD) is clinically diagnosed for the
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …
presence of principal biomarkers, especially misfolded amyloid-beta (Aβ) and tau proteins in …
[HTML][HTML] Implications of GABAergic neurotransmission in Alzheimer's disease
Y Li, H Sun, Z Chen, H Xu, G Bu… - Frontiers in aging …, 2016 - frontiersin.org
Alzheimer's disease (AD) is characterized pathologically by the deposition of β-amyloid
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …
peptides (Aβ) and the accumulation of neurofibrillary tangles (NFTs) composed of hyper …