The histopathological hallmark of Parkinson's disease (PD) is the presence of fibrillar
aggregates referred to as Lewy bodies (LBs), in which α-synuclein is a major constituent …

Protein misfolding, aggregation and deposition are common disease mechanisms in many
neurodegenerative diseases including Parkinson's disease (PD). Accumulation of damaged …

Increased autophagic vacuoles (AVs) occur in injured or degenerating neurons, under both
developmental and pathological situations. Although regulation of starvation-induced …

Parkinson's disease (PD) is a common neurodegenerative disorder. Neuronal cell death in
PD is still poorly understood, despite a wealth of potential pathogenic mechanisms and …

Proteasomal dysfunction may play a role in neurodegenerative conditions and protein
aggregation. Overexpression in neuronal cells of α-synuclein, a molecule linked to …

Parkinson's disease (PD) is a neurodegenerative disease characterized by the selective
loss of dopamine (DA) neurons and the presence of α-synuclein (AS) aggregates as Lewy …

The ubiquitin–proteasome system (UPS) and the autophagy-lysosomal pathway (ALP) are
the two most important cellular mechanisms for protein degradation. To investigate the role …

In eukaryotic cells, degradation of most intracellular proteins is realized by proteasomes.
The substrates for proteolysis are selected by the fact that the gate to the proteolytic chamber …

Parkinson's disease (PD) is an age‐related movement disorder resulting, in part, from
selective loss of dopaminergic neurons. Both invertebrate and mammalian models have …

The pathological hallmarks of Parkinson's disease are the progressive loss of nigral
dopaminergic neurons and the formation of intracellular inclusion bodies, termed Lewy …