Reperfusion of the heart after a period of ischaemia leads to the opening of a nonspecific
pore in the inner mitochondrial membrane, known as the mitochondrial permeability …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

The mitochondrion is a major source of reactive oxygen species (ROS). Superoxide (O2•−)
is generated under specific bioenergetic conditions at several sites within the electron …

Limitation of infarct size by ischemic/pharmacological pre-and postconditioning involves
activation of a complex set of cell-signaling pathways. Multiple lines of evidence implicate …

The production of reactive oxygen species by the mitochondrial complex II (succinate:
ubiquinone oxidoreductase) recently has gained broad scientific interest. Depending on the …

A prolonged period of ischaemia followed by reperfusion irreversibly damages the heart.
Such reperfusion injury (RI) involves opening of the mitochondrial permeability transition …

Coronary artery disease and its sequelae—ischemia, myocardial infarction, and heart failure—
are leading causes of morbidity and mortality in man. Considerable effort has been devoted …

Despite a high prevalence of sudden cardiac death throughout the world, the mechanisms
that lead to ventricular arrhythmias are not fully understood. Over the last 20 years, a …

In this review, we summarize our knowledge about mitochondrial potassium channels, with
a special focus on unanswered questions in this field. The following potassium channels …

IMPLICATIONS: Sevoflurane protects against myocardial ischemia-reperfusion injury when
given before (preconditioning) or after (postconditioning) myocardial ischemia. Both effects …