Snake venoms often contain toxins that cause a rapid necrosis of skeletal muscle fibers,
referred to as myotoxins. The most common among them are phospholipases A2 (PLA2s) …

Muscle necrosis is a potential clinical complication of snakebite envenomings, which in
severe cases can lead to functional or physical sequelae such as disability or amputation …

Toxins are natural or chemical poisonous substances with severe side effects on health.
Humans are generally exposed by widespread toxic contaminations via air, soil, water, food …

Envenomation via snakebites is an important public health problem in many tropical and
subtropical countries that, in addition to mortality, can result in permanent sequelae as a …

A particular subgroup of toxins with phospholipase A2 (PLA2) structure, but devoid of this
enzymatic activity, is commonly found in the venoms of snakes of the family Viperidae, and …

Phospholipases A2 constitute the major components from Bothrops snake venoms and have
been extensively investigated not only because they are relatively very abundant in these …

MjTX-II, a myotoxic phospholipase A2 (PLA2) homologue from Bothrops moojeni venom,
was functionally and structurally characterized. The MjTX-II characterization included:(i) …

Unraveling the repertoire of venom toxins of Bothropoides pauloensis was assessed by
snake venomics and venom gland transcriptomic surveys. Both approaches yielded …

Phospholipase A2 (PLA2, EC 3.1. 1.4), a major component of snake venoms, specifically
catalyzes the hydrolysis of fatty acid ester bonds at position 2 of 1, 2-diacyl-sn-3 …

This work shows the antitumoral effects of BnSP-6, a Lys 49 PLA 2 isolated from Bothrops
pauloensis venom, on human breast cancer MDA-MB-231 cells. BnSP-6 caused a dose …