Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
The nature of embryonic stem cells
G Martello, A Smith - Annual review of cell and developmental …, 2014 - annualreviews.org
Mouse embryonic stem (ES) cells perpetuate in vitro the broad developmental potential of
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
naïve founder cells in the preimplantation embryo. ES cells self-renew relentlessly in culture …
Assembly of embryonic and extraembryonic stem cells to mimic embryogenesis in vitro
SE Harrison, B Sozen, N Christodoulou, C Kyprianou… - Science, 2017 - science.org
INTRODUCTION Early mammalian development requires the formation of embryonic and
extraembryonic tissues and a highly coordinated partnership between them. This close …
extraembryonic tissues and a highly coordinated partnership between them. This close …
Reactivation of the pluripotency program precedes formation of the cranial neural crest
INTRODUCTION Cell differentiation is classically described as a unidirectional process that
progresses through a series of lineage restriction events, with cellular potential being …
progresses through a series of lineage restriction events, with cellular potential being …
Core transcriptional regulatory circuitry in human embryonic stem cells
The transcription factors OCT4, SOX2, and NANOG have essential roles in early
development and are required for the propagation of undifferentiated embryonic stem (ES) …
development and are required for the propagation of undifferentiated embryonic stem (ES) …
[HTML][HTML] Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4
Oct4 is a mammalian POU transcription factor expressed by early embryo cells and germ
cells. We report that the activity of Oct4 is essential for the identity of the pluripotential …
cells. We report that the activity of Oct4 is essential for the identity of the pluripotential …
The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells
K Mitsui, Y Tokuzawa, H Itoh, K Segawa, M Murakami… - Cell, 2003 - cell.com
Embryonic stem (ES) cells derived from the inner cell mass (ICM) of blastocysts grow
infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self …
infinitely while maintaining pluripotency. Leukemia inhibitory factor (LIF) can maintain self …
Nanog safeguards pluripotency and mediates germline development
Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and
developing germ cells,. Deletion of Nanog causes early embryonic lethality, whereas …
developing germ cells,. Deletion of Nanog causes early embryonic lethality, whereas …
[HTML][HTML] Common stemness regulators of embryonic and cancer stem cells
C Hadjimichael, K Chanoumidou… - World journal of stem …, 2015 - ncbi.nlm.nih.gov
Pluripotency of embryonic stem cells (ESCs) and induced pluripotent stem cells is regulated
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
by a well characterized gene transcription circuitry. The circuitry is assembled by ESC …
[HTML][HTML] MicroRNA-145 regulates OCT4, SOX2, and KLF4 and represses pluripotency in human embryonic stem cells
N Xu, T Papagiannakopoulos, G Pan, JA Thomson… - Cell, 2009 - cell.com
MicroRNAs (miRNAs) are posttranscriptional modulators of gene expression and play an
important role in many developmental processes. We report here that expression of …
important role in many developmental processes. We report here that expression of …