Brainstem respiratory networks: building blocks and microcircuits

JC Smith, APL Abdala, A Borgmann, IA Rybak… - Trends in …, 2013 - cell.com
Breathing movements in mammals are driven by rhythmic neural activity generated within
spatially and functionally organized brainstem neural circuits comprising the respiratory …

Understanding the rhythm of breathing: so near, yet so far

JL Feldman, CA Del Negro… - Annual review of …, 2013 - annualreviews.org
Breathing is an essential behavior that presents a unique opportunity to understand how the
nervous system functions normally, how it balances inherent robustness with a highly …

Cardiorespiratory coupling: common rhythms in cardiac, sympathetic, and respiratory activities

TE Dick, YH Hsieh, RR Dhingra, DM Baekey… - Progress in brain …, 2014 - Elsevier
Cardiorespiratory coupling is an encompassing term describing more than the well-
recognized influences of respiration on heart rate and blood pressure. Our data indicate that …

Role of inhibition in respiratory pattern generation

WA Janczewski, A Tashima, P Hsu, Y Cui… - Journal of …, 2013 - Soc Neuroscience
Postsynaptic inhibition is a key element of neural circuits underlying behavior, with 20–50%
of all mammalian (nongranule) neurons considered inhibitory. For rhythmic movements in …

Organization of the core respiratory network: insights from optogenetic and modeling studies

J Ausborn, H Koizumi, WH Barnett… - PLoS computational …, 2018 - journals.plos.org
The circuit organization within the mammalian brainstem respiratory network, specifically
within and between the pre-Bötzinger (pre-BötC) and Bötzinger (BötC) complexes, and the …

Advancing respiratory–cardiovascular physiology with the working heart–brainstem preparation over 25 years

JFR Paton, BH Machado, DJA Moraes… - The Journal of …, 2022 - Wiley Online Library
Twenty‐five years ago, a new physiological preparation called the working heart–brainstem
preparation (WHBP) was introduced with the claim it would provide a new platform allowing …

Proton detection and breathing regulation by the retrotrapezoid nucleus

PG Guyenet, DA Bayliss, RL Stornetta… - The Journal of …, 2016 - Wiley Online Library
We discuss recent evidence which suggests that the principal central respiratory
chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons …

Computational models of the neural control of breathing

YI Molkov, JE Rubin, IA Rybak… - … : Systems Biology and …, 2017 - Wiley Online Library
The ongoing process of breathing underlies the gas exchange essential for mammalian life.
Each respiratory cycle ensues from the activity of rhythmic neural circuits in the brainstem …

[HTML][HTML] Computational models and emergent properties of respiratory neural networks

BG Lindsey, IA Rybak, JC Smith - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Computational models of the neural control system for breathing in mammals provide a
theoretical and computational framework bringing together experimental data obtained from …

Interacting oscillations in neural control of breathing: modeling and qualitative analysis

JE Rubin, BJ Bacak, YI Molkov, NA Shevtsova… - Journal of computational …, 2011 - Springer
In mammalian respiration, late-expiratory (late-E, or pre-inspiratory) oscillations emerge in
abdominal motor output with increasing metabolic demands (eg, during hypercapnia …