For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

In this study, we investigated whether mesenchymal stem cells (MSC) had
immunomodulatory properties in solid organ allotransplantation, using a semiallogeneic …

The achievement of immune tolerance, a state of specific unresponsiveness to the donor
graft, has the potential to overcome the current major limitations to progress in organ …

The main objective of immunology is to establish why and when an immune response
occurs, that is, to determine a criterion of immunogenicity. According to the consensus view …

Establishment of mixed chimerism through transplantation of allogeneic donor bone marrow
(BM) into sufficiently conditioned recipients is an effective experimental approach for the …

Hematopoietic cell transplantation can correct hematological and immunological disorders
by replacing a diseased blood system with a healthy one, but this currently requires …

To investigate the antigen specificity of regulatory T cells capable of preventing transplant
rejection, we have developed two different strategies to achieve tolerance to fully …

We investigated the effect of autologous mesenchymal stem cells (MSC) on multiple
unmodified donor bone marrow (BM) infusions and vascularized skin graft outcome. BM …

The self/non-self model, first proposed by FM Burnet, has dominated immunology for 60
years now. According to this model, any foreign element will trigger an immune reaction in …

Peripheral and central clonal deletion are important tolerance mechanisms in models using
bone marrow transplantation (BMT) with costimulation blockade (CB). However, since …