The ever increasing computer power, together with the improved accuracy of atomistic force
fields, enables researchers to investigate biological systems at the molecular level with …

Highlights•Knotted proteins span diverse biological functions and cover∼ 1% of all PDB
entries.•Reaching their knotted native states requires a concerted series of folding …

Elastic network models, simple structure-based representations of biomolecules where
atoms interact via short-range harmonic potentials, provide great insight into a molecule's …

Knots in proteins are hypothesized to make them resistant to enzymatic degradation by ATP-
dependent proteases and recent studies have shown that whereas ClpXP can easily …

While the slipknot topology in proteins has been known for over a decade, its evolutionary
origin is still a mystery. We have identified a previously overlooked slipknot motif in a family …

Entanglement and knots occur across all aspects of the physical world. Despite the common
belief that knots are too complicated for incorporation into proteins, knots have been …

Molecular dynamics simulations are used to explore the effects of chaperonin-like cages on
knotted proteins with very low sequence similarity, different depths of a knot but with a …

There is growing support for the idea that the in vivo folding process of knotted proteins is
assisted by chaperonins, but the mechanism of chaperonin assisted folding remains elusive …

The existence of self-entangled proteins, the native structure of which features a complex
topology, unveils puzzling, and thus fascinating, aspects of protein biology and evolution …

Spatial confinement limits the conformational space accessible to biomolecules but the
implications for bimolecular topology are not yet known. Folded linear biopolymers can be …