The Hippo pathway is an evolutionarily conserved signalling pathway with key roles in
organ development, epithelial homeostasis, tissue regeneration, wound healing and …

The cell adhesion molecule CADM1, which participates in cell adhesion and signal
transduction, has a regulatory effect on the development of tumors. CADM1 is often involved …

During epithelial-mesenchymal transition (EMT) epithelial cancer cells transdifferentiate into
highly motile, invasive, mesenchymal-like cells, giving rise to disseminating tumor cells. Few …

Survival for high-risk neuroblastoma remains poor and treatment for relapsed disease rarely
leads to long-term cures. Large sequencing studies of neuroblastoma tumors from diagnosis …

Relapsed neuroblastomas are enriched with activating mutations of the RAS–MAPK
signaling pathway. The MEK1/2 inhibitor trametinib delays tumor growth but does not …

CHD5, a tumor suppressor at 1p36, is frequently lost or silenced in poor prognosis
neuroblastoma (NB) and many adult cancers. The role of CHD5 in metastasis is unknown …

Despite multi-modality treatments, prognosis for advanced stage neuroblastoma (NB)
remains challenging with residual long-term disabilities in survivors. Advanced stage NB is …

Neuroblastoma is an aggressive pediatric malignancy of the neural crest with suboptimal
cure rates and a striking predilection for widespread metastases, underscoring the need to …

Sphingosine kinase 1 (Sphk1) is a highly conserved lipid kinase that phosphorylates
sphingosine to form sphingosine-1-phosphate (S1P). Growing studies have demonstrated …

The survival rate among children with relapsed neuroblastomas continues to be poor, and
thus new therapeutic approaches identified by reliable preclinical drug testing models are …