Approximately 33% of melanomas are derived directly from benign, melanocytic nevi.
Despite this, the vast majority of melanocytic nevi, which typically form as a result of BRAF …

Melanoma is the most deadly of the common skin cancers and its incidence is rapidly
increasing. Approximately 10% of cases occur in a familial context. To date, cyclin …

Importance Melanoma is epidemiologically linked to UV exposure, particularly childhood
sunburn. Public health campaigns are increasing sun-protective behavior in the United …

Histopathological evaluation of melanocytic tumours usually allows reliable distinction of
benign melanocytic naevi from melanoma. More difficult is the histopathological …

Most of our current knowledge of melanoma is derived from the study of patients from
populations of European descent, for whom public health, sun protection initiatives and …

A family history of melanoma greatly increases the risk of developing cutaneous melanoma,
a highly aggressive skin cancer whose incidence has been steadily increasing worldwide …

Background An estimated 5%–10% of all cutaneous melanoma cases occur in families. This
review describes susceptibility genes currently known to be involved in melanoma …

MicroRNAs (miRNAs) are a class of 22–25 nucleotide RNAs that control gene expression at
the post-transcriptional level. MiRNAs have potential as cancer biomarkers. Melanoma is a …

Melanoma is a deadly skin cancer that becomes especially difficult to treat after it
metastasizes. Timely identification of melanoma is critical for effective therapy, but …

Cutaneous melanoma (CM) and uveal melanoma (UM) derive from cutaneous and uveal
melanocytes that share the same embryonic origin and display the same cellular function …