Conventional chemotherapeutics and targeted antineoplastic agents have been developed
based on the simplistic notion that cancer constitutes a cell-autonomous genetic or …

Immune responses occur in the midst of a variety of cellular stresses that can severely
perturb endoplasmic reticulum (ER) function. The unfolded protein response is a three …

Mitotic catastrophe is distinct from other cell death modes due to unique nuclear alterations
characterized as multi and/or micronucleation. Mitotic catastrophe is a common and virtually …

Accumulating evidence suggests that the clinical efficacy of selected anticancer drugs,
including conventional chemotherapeutics as well as targeted anticancer agents, originates …

Oncolytic viruses are natural or genetically modified viral species that selectively infect and
kill neoplastic cells. Such an innate or exogenously conferred specificity has generated …

The long-established notion that apoptosis would be immunologically silent, and hence it
would go unnoticed by the immune system, if not tolerogenic, and hence it would actively …

MHC class I molecules display oligopeptides on the cell surface to enable T cell
immunosurveillance of intracellular pathogens and tumors. Speed is of the essence in …

In 1997, for the first time in history, a monoclonal antibody (mAb), ie, the chimeric anti-CD20
molecule rituximab, was approved by the US Food and Drug Administration for use in …

Background Little is known about the immunological effect of neoadjuvant
chemoradiotherapy (NACRT) in the tumor microenvironment of pancreatic ductal …

In a series of 248 tumor samples obtained from image-guided biopsies from patients
diagnosed with ductal carcinoma in situ of the breast, we attempted to identify biomarkers …