Alzheimer's disease (AD) is neuropathologically characterized by the intracellular
accumulation of hyperphosphorylated tau and the extracellular deposition of amyloid-β …

Galanin was first identified 30 years ago as a" classic neuropeptide," with actions primarily
as a modulator of neurotransmission in the brain and peripheral nervous system. Other …

Alzheimer's disease (AD) is the most common form of degenerative dementia and is
characterized by progressive impairment in cognitive function during mid-to late-adult life …

The galanin peptide family consists of the “parental” galanin, galanin-message-associated
peptide (GMAP) which derives from the same peptide precursor gene product as galanin …

The basal forebrain cholinergic system (BFCS) has long been implicated in age-related
cognitive changes and the pathophysiology of Alzheimer's disease (AD). Limitations of …

Parkinson's disease (PD) affects approximately 1% of the world's aging population. Despite
its prevalence and rigorous research in both humans and animal models, the etiology …

The present invention relates to a first group of novel genes, here identified as “genomic
address messenger” or “GAM” genes, and a second group of novel operon-like genes, here …

Forebrain cholinergic neurons play important roles as striatal local circuit neurons and basal
telencephalic projection neurons. The genetic mechanisms that control development of …

Recent molecular cloning studies have established the existence of a third rat galanin
receptor subtype, GalR3, however its precise distribution in the mammalian central nervous …

The neuropeptide galanin is expressed developmentally in the dorsal root ganglion (DRG)
and is rapidly up-regulated 120-fold after peripheral nerve section in the adult. Here we …