Streptomyces Endophytes Promote Host Health and Enhance Growth across Plant Species

SF Worsley, J Newitt, J Rassbach… - Applied and …, 2020 - Am Soc Microbiol
Streptomyces bacteria are ubiquitous in soils and are well known for producing secondary
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots …

Beyond soil-dwelling actinobacteria: Fantastic antibiotics and where to find them

J Santos-Aberturas, NM Vior - Antibiotics, 2022 - mdpi.com
Bacterial secondary metabolites represent an invaluable source of bioactive molecules for
the pharmaceutical and agrochemical industries. Although screening campaigns for the …

Antarctic Streptomyces fildesensis So13.3 strain as a promising source for antimicrobials discovery

K Núñez-Montero, C Lamilla, M Abanto, F Maruyama… - Scientific reports, 2019 - nature.com
Antarctic have been suggested as an attractive source for antibiotics discovery and
members of Streptomyces genus have historically been studied as natural producers of …

Re-wiring the regulation of the formicamycin biosynthetic gene cluster to enable the development of promising antibacterial compounds

R Devine, HP McDonald, Z Qin, CJ Arnold, K Noble… - Cell chemical …, 2021 - cell.com
The formicamycins are promising antibiotics first identified in Streptomyces formicae KY5,
which produces the compounds at low levels. Here, we show that by understanding the …

A role for antibiotic biosynthesis monooxygenase domain proteins in fidelity control during aromatic polyketide biosynthesis

Z Qin, R Devine, MI Hutchings, B Wilkinson - Nature communications, 2019 - nature.com
The formicamycin biosynthetic gene cluster encodes two groups of type 2 polyketide
antibiotics: the formicamycins and their biosynthetic precursors the fasamycins, both of …

Competition-based screening helps to secure the evolutionary stability of a defensive microbiome

SF Worsley, TM Innocent, NA Holmes, MM Al-Bassam… - BMC biology, 2021 - Springer
Background The cuticular microbiomes of Acromyrmex leaf-cutting ants pose a conundrum
in microbiome biology because they are freely colonisable, and yet the prevalence of the …

Phylogenomic analyses and distribution of terpene synthases among Streptomyces

L Martín-Sánchez, KS Singh, M Avalos… - Beilstein journal of …, 2019 - beilstein-journals.org
Terpene synthases are widely distributed among microorganisms and have been mainly
studied in members of the genus Streptomyces. However, little is known about the …

Heterologous expression of the formicamycin biosynthetic gene cluster unveils glycosylated fasamycin congeners

HP McDonald, A Alford, R Devine… - Journal of Natural …, 2023 - ACS Publications
Formicamycins and their biosynthetic intermediates the fasamycins are polyketide antibiotics
produced by Streptomyces formicae KY5 from a pathway encoded by the for biosynthetic …

Antimicrobial-producing microorganisms in fungus-farming ants: a critical review on insights into a natural biological defense with biotechnological potential

JV Maurice-Lira, J Romero-Nápoles… - Annals of the …, 2024 - academic.oup.com
The main function of symbiotic actinobacterias in fungus-farming ants (Formicidae:
Myrmicinae: Attini) is to protect the cultivated fungus against the pathogenic fungus …

Incipient genome erosion and metabolic streamlining for antibiotic production in a defensive symbiont

TY Nechitaylo, M Sandoval-Calderón… - Proceedings of the …, 2021 - National Acad Sciences
Genome erosion is a frequently observed result of relaxed selection in insect nutritional
symbionts, but it has rarely been studied in defensive mutualisms. Solitary beewolf wasps …