HMGB proteins are members of the High Mobility Group (HMG) superfamily, possessing a
unique DNA-binding domain, the HMG-box, which can bind non-B-type DNA structures …

Although the three families of mammalian HMG proteins (HMGA, HMGB and HMGN)
participate in many of the same nuclear processes, each family plays its own unique role in …

We present a novel method utilizing" saltless" pH gradient weak cation exchange-
hydrophilic interaction liquid chromatography directly coupled to electron transfer …

Because of the critical role of neuroinflammation in various neurological diseases, there are
continuous efforts to identify new therapeutic targets as well as new therapeutic agents to …

Objective To address mechanisms that control the activity of human peptidyl arginine
deiminase type 4 (PAD‐4). Methods PAD‐4 autocitrullination was determined by anti …

Chromatin is a dynamic complex of DNA and proteins that regulates the flow of information
from genome to end product. The efficient recognition and faithful repair of DNA damage …

The human Polybromo-1 protein (Pb1) was recently identified as a unique subunit of the
PBAF (Polybromo, Brg1-Associated Factors) chromatin-remodeling complex required for …

Nuclear functions rely on the activity of a plethora of factors which mostly work in highly
coordinated molecular networks. The HMGA proteins are chromatin architectural factors …

The functioning of DNA in the cell nucleus is ensured by a multitude of proteins, whose
interactions with DNA as well as with other proteins lead to the formation of a complicated …

The architectural DNA-binding protein HMGB1 consists of two tandem HMG-box domains
joined by a basic linker to a C-terminal acidic tail, which negatively regulates HMGB1–DNA …