Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise adaptation using timed in vivo myonuclear labeling
Muscle fibers are syncytial postmitotic cells that can acquire exogenous nuclei from resident
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …
The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain
LM Weber, Y Jia, B Stielow… - Nucleic acids …, 2023 - academic.oup.com
The lysine acetyltransferase KAT6A (MOZ, MYST3) belongs to the MYST family of chromatin
regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in …
regulators, facilitating histone acetylation. Dysregulation of KAT6A has been implicated in …
The CpG island-binding protein SAMD1 contributes to an unfavorable gene signature in hepg2 hepatocellular carcinoma cells
C Simon, B Stielow, A Nist, I Rohner, LM Weber… - Biology, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) belongs to the most common cancer
types and is the third leading cause of cancer-related deaths. To gain insight into the …
types and is the third leading cause of cancer-related deaths. To gain insight into the …
Investigation of SAMD1 ablation in mice
B Campbell, LM Weber, SJ Engle, TRS Ozolinš… - Scientific Reports, 2023 - nature.com
SAM domain-containing protein 1 (SAMD1) has been implicated in atherosclerosis, as well
as in chromatin and transcriptional regulation, suggesting a versatile and complex biological …
as in chromatin and transcriptional regulation, suggesting a versatile and complex biological …
SAMD1 suppresses epithelial–mesenchymal transition pathways in pancreatic ductal adenocarcinoma
C Simon, ID Brunke, B Stielow, I Forné, AM Steitz… - PLoS …, 2024 - journals.plos.org
Pancreatic ductal adenocarcinoma (PDAC) poses a significant threat due to its tendency to
evade early detection, frequent metastasis, and the subsequent challenges in devising …
evade early detection, frequent metastasis, and the subsequent challenges in devising …
SAMD1 distribution patterns in mouse atherosclerosis models suggest roles in LDL retention, antigen presentation, and cell phenotype modulation
B Campbell, P Bourassa, R Aiello - Biorxiv, 2021 - biorxiv.org
The theory that lesions formed by retention of circulating LDL can then progress to
complicated atherosclerotic lesions has been a subject of debate, as has the mechanism of …
complicated atherosclerotic lesions has been a subject of debate, as has the mechanism of …
[HTML][HTML] Identification of survival-associated biomarkers based on three datasets by bioinformatics analysis in gastric cancer
LK Yin, HY Yuan, JJ Liu, XL Xu, W Wang… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Gastric cancer (GC) is one of the most common malignant tumors with poor
prognosis in terms of advanced stage. However, the survival-associated biomarkers for GC …
prognosis in terms of advanced stage. However, the survival-associated biomarkers for GC …
Ablation of SAMD1 in mice causes failure of angiogenesis, embryonic lethality
B Campbell, S Engle, T Ozolins, P Bourassa, R Aiello - bioRxiv, 2022 - biorxiv.org
Pathological retention of LDL in the intima is involved in atherosclerosis, although the
retention mechanisms are not well-understood. Previously, we reported Sterile Alpha Motif …
retention mechanisms are not well-understood. Previously, we reported Sterile Alpha Motif …
[HTML][HTML] Epigenetic Regulation of Cell Signaling: Epigenetic evidence for distinct contributions of resident and acquired myonuclei during long-term exercise …
KA Murach, CM Dungan, F von Walden… - American Journal of …, 2022 - ncbi.nlm.nih.gov
Muscle fibers are syncytial postmitotic cells that can acquire exogenous nuclei from resident
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …
muscle stem cells, called satellite cells. Myonuclei are added to muscle fibers by satellite …
Characterization of histone acetyltransferase KAT6A and transcriptional repressor SAMD1–two proteins possessing a novel class of unmethylated DNA-binding …
LM Weber - 2023 - archiv.ub.uni-marburg.de
This thesis addresses the functions of two transcriptional regulators; histone
acetyltransferase and transcriptional activator KAT6A (MOZ), and transcriptional repressor …
acetyltransferase and transcriptional activator KAT6A (MOZ), and transcriptional repressor …