Identification of 1, 3, 4-oxadiazolyl-containing β-carboline derivatives as novel α-glucosidase inhibitors with antidiabetic activity
D Xiao, L Lu, B Liang, Z Xiong, X Xu… - European Journal of …, 2023 - Elsevier
In this study, we designed and synthesized a novel class of 1, 3, 4-oxadiazolyl-containing β-
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
carboline derivatives, ie, compounds f1∼ f35 as potential α-glucosidase inhibitors. All the …
Syntheses, reactivity, and biological applications of coumarins
This comprehensive review, covering 2021–2023, explores the multifaceted chemical and
pharmacological potential of coumarins, emphasizing their significance as versatile natural …
pharmacological potential of coumarins, emphasizing their significance as versatile natural …
Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking …
In the present work, a small library of novel pyrazolinyl-acyl thiourea (5a–j) was designed
and synthesized through a multistep sequence and the synthesized compounds were …
and synthesized through a multistep sequence and the synthesized compounds were …
Synthesis, anti-α-glucosidase activity, inhibition interaction, and anti-diabetic activity of novel cryptolepine derivatives
M Feng, B Liang, J Sun, X Min, SH Wang, Y Lu… - Journal of Molecular …, 2024 - Elsevier
To find potential α-glucosidase inhibitors, thirty-seven cryptolepine derivatives (FM1∼ 37)
were designed and synthesized. Compared to parent compound cryptolepine (IC 50 …
were designed and synthesized. Compared to parent compound cryptolepine (IC 50 …
Synthesis, biological evaluation, and molecular docking study of chromen‐linked hydrazine carbothioamides as potent α‐glucosidase inhibitors
Inhibiting α‐glucosidase is a reliable method for reducing blood sugar levels in diabetic
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
individuals. Several novel chromen‐linked hydrazine carbothioamide (3a–r) were designed …
Novel molecular hybrids of EGCG and quinoxaline: Potent multi-targeting antidiabetic agents that inhibit α-glucosidase, α-amylase, and oxidative stress
M Kothari, K Kannan, R Sahadevan… - International Journal of …, 2024 - Elsevier
Diabetes mellitus is a multifactorial disease and its effective therapy often demands several
drugs with different modes of action. Herein, we report a rational design and synthesis of …
drugs with different modes of action. Herein, we report a rational design and synthesis of …
Synthesis of novel coumarin–hydrazone hybrids as α-glucosidase inhibitors and their molecular docking studies
Diabetes mellitus is a metabolic disorder and more than 90% of diabetic patients suffer from
type-2 diabetes, which is characterized by hyperglycemia. α-Glucosidase inhibition has …
type-2 diabetes, which is characterized by hyperglycemia. α-Glucosidase inhibition has …
Evaluation of Ternary Thiazole-Coumarin-Azomethine Derivatives as Multi-Target Inhibitors: α-Amylase, Urease, Free Radical Scavenging and Antibacterial Activities …
Present studies primarily demonstrate the evaluation of ternary thiazole-coumarin-
azomethine derivatives for their in-vitro assessment against α-amylase, urease …
azomethine derivatives for their in-vitro assessment against α-amylase, urease …