[HTML][HTML] Cell cycle regulation: p53-p21-RB signaling
K Engeland - Cell Death & Differentiation, 2022 - nature.com
The retinoblastoma protein RB and the transcription factor p53 are central tumor
suppressors. They are often found inactivated in various tumor types. Both proteins play …
suppressors. They are often found inactivated in various tumor types. Both proteins play …
[HTML][HTML] Mechanisms of cellular senescence: cell cycle arrest and senescence associated secretory phenotype
R Kumari, P Jat - Frontiers in cell and developmental biology, 2021 - frontiersin.org
Cellular senescence is a stable cell cycle arrest that can be triggered in normal cells in
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
response to various intrinsic and extrinsic stimuli, as well as developmental signals …
Blocking PD-L1–PD-1 improves senescence surveillance and ageing phenotypes
The accumulation of senescent cells is a major cause of age-related inflammation and
predisposes to a variety of age-related diseases. However, little is known about the …
predisposes to a variety of age-related diseases. However, little is known about the …
[HTML][HTML] Coordinating gene expression during the cell cycle
Cell cycle-dependent gene transcription is tightly controlled by the retinoblastoma (RB): E2F
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
and DREAM complexes, which repress all cell cycle genes during quiescence. Cyclin …
[HTML][HTML] Dual proteome-scale networks reveal cell-specific remodeling of the human interactome
Thousands of interactions assemble proteins into modules that impart spatial and functional
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
organization to the cellular proteome. Through affinity-purification mass spectrometry, we …
The multiple mechanisms that regulate p53 activity and cell fate
A Hafner, ML Bulyk, A Jambhekar… - Nature reviews Molecular …, 2019 - nature.com
The tumour suppressor p53 has a central role in the response to cellular stress. Activated
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
p53 transcriptionally regulates hundreds of genes that are involved in multiple biological …
[HTML][HTML] Ki-67 gene expression
S Uxa, P Castillo-Binder, R Kohler, K Stangner… - Cell Death & …, 2021 - nature.com
Ki-67 serves as a prominent cancer marker. We describe how expression of the MKI67 gene
coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are …
coding for Ki-67 is controlled during the cell cycle. MKI67 mRNA and Ki-67 protein are …
[HTML][HTML] Ki67 is a graded rather than a binary marker of proliferation versus quiescence
Ki67 staining is widely used as a proliferation indicator in the clinic, despite poor
understanding of this protein's function or dynamics. Here, we track Ki67 levels under …
understanding of this protein's function or dynamics. Here, we track Ki67 levels under …
[HTML][HTML] Human papillomavirus E6 and E7: the cervical cancer hallmarks and targets for therapy
Human papillomavirus (HPV)-induced cervical cancer is a major health issue among
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …
women from the poorly/under-developed sectors of the world. It accounts for a high-mortality …
[HTML][HTML] Census and evaluation of p53 target genes
M Fischer - Oncogene, 2017 - nature.com
The tumor suppressor p53 functions primarily as a transcription factor. Mutation of the TP53
gene alters its response pathway, and is central to the development of many cancers. The …
gene alters its response pathway, and is central to the development of many cancers. The …