Sharp wave ripples (SPW‐Rs) represent the most synchronous population pattern in the
mammalian brain. Their excitatory output affects a wide area of the cortex and several …

The entorhinal cortex–hippocampus complex is believed to be the site of origin of seizure
activity in the majority of patients with temporal lobe epilepsy (TLE). Both these regions are …

Neurones generate intrinsic subthreshold membrane potential oscillations (MPOs) under
various physiological and behavioural conditions. These oscillations influence neural …

The cholinergic system is thought to play an important role in hippocampal-dependent
learning and memory. However, the mechanism of action of the cholinergic system in these …

There is considerable interest in identifying pharmacological compounds that could be used
to facilitate fear extinction. Recently, we showed that the modulation of M-type K+ channels …

CA1 pyramidal neurons from animals that have acquired a hippocampus-dependent task
show a reduced slow postburst afterhyperpolarization (sAHP). To understand the functional …

Cholinergic input from the basal forebrain and septum to the hippocampus is well known to
be critical in learning and memory. Muscarinic induction of theta‐frequency oscillations may …

We investigated the effects of 5‐hydroxytryptamine (5‐HT, serotonin) in striatal cholinergic
interneurones with gramicidin‐perforated whole‐cell patch recordings. Bath‐application of …

Commonly used inbred murine strains differ substantially in their vulnerability to excitotoxic
insults. We investigated whether differences in dendritic Ca2+ signaling could underlie the …

Metabotropic receptors modulate numerous cellular processes by intracellular Ca2+
signaling, but less is known about their role in regulating mitochondrial metabolic function …