Amyotrophic lateral sclerosis (ALS) is an intractable disease that causes respiratory failure
leading to mortality. The main locus of ALS is motor neurons. The success of antisense …

Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) have a strong
clinical, genetic and pathological overlap. This review focuses on the current understanding …

Abstract Objective Mutations in Fused in Sarcoma (FUS or TLS) are the fourth most
prevalent in Western European familial amyotrophic lateral sclerosis (ALS) populations and …

Amyotrophic lateral sclerosis (ALS) is a late-onset motor neuron disorder. Although its
neuropathology is well understood, the cellular and molecular mechanisms are yet to be …

Background The characteristic structure of motor neurons (MNs), particularly of the long
axons, becomes damaged in the early stages of amyotrophic lateral sclerosis (ALS) …

Amyotrophic lateral sclerosis (ALS) is an adult-onset neurodegenerative disease
characterized by loss of motor neurons. We have recently identified SOD1 and FUS …

Genetic abnormalities play a crucial role in the development of neurodegenerative disorders
(NDDs). Genetic exploration has indeed contributed to unraveling the molecular …

Hepatocyte growth factor is an endogenous pleiotropic factor shown to act as a potent
neuroprotectant against disease progression in animal models of amyotrophic lateral …

3. Discussion To the best of our knowledge, this familial case study is the first Asian familial
ALS case report with a TARDBP p. G376D mutation, in which the clinical phenotype was …

Advanced pathological and genetic approaches have revealed that mutations in fused in
sarcoma/translated in liposarcoma (FUS/TLS), which is pivotal for DNA repair, alternative …