Glucokinase, which phosphorylates glucose to form glucose‐6‐phosphate, plays a critical
role in regulating blood glucose levels. On the basis of data of glucokinase‐knockout and …

The Carbohydrate response element binding protein, ChREBP encoded by the MLXIPL
gene, is a transcription factor that is expressed at high levels in the liver and has a prominent …

Abstract Objectives The Glucokinase Regulatory Protein GKRP, encoded by GCKR, enables
acute regulation of liver glucokinase to support metabolic demand. The common human …

Mutations in glucokinase (GCK) can either enhance or inhibit insulin secretion, leading to
different forms of diabetes, including gestational diabetes. While many glucokinase …

Aim To investigate how subchronic administration of a glucokinase activator (GKA) results in
attenuation of the hypoglycaemic effect in the diabetic condition. Materials and Methods Six …

Glucokinase activators are regarded as potent candidates for diabetes treatment, however,
in clinical studies on patients with type 2 diabetes, a diminishing efficacy was observed after …

非酒精性脂肪性肝病(NAFLD) 是一种常见疾病, 病理表现为肝细胞内脂肪滴大量蓄积. NAFLD
不仅成因复杂, 还可诱发心血管疾病, 糖尿病等, 然而目前尚无有效的治疗手段和专门的治疗药物 …

Glucokinase activators (GKAs) have been developed as blood glucose lowering drugs for
type 2 diabetes. Despite good short-term efficacy, several GKAs showed a decline in efficacy …

Background and aims Type 2 diabetes mellitus remains a substantial medical problem with
increasing global prevalence. Pharmacological research is becoming increasingly focused …

I investigated mouse models to elucidate the pathophysiology and to establish a new
treatment strategy for type 2 diabetes, with a particular focus on glucokinase. The decrease …