Brain function critically depends on a close matching between metabolic demands,
appropriate delivery of oxygen and nutrients, and removal of cellular waste. This matching …

Vascular cognitive impairment and dementia (VCID) is commonly caused by vascular
injuries in cerebral large and small vessels and is a key driver of age-related cognitive …

The prevalence of cerebrovascular disease increases with age, placing the elderly at a
greater lifetime risk for dementia. Vascular cognitive impairment (VCI) encompasses a …

White matter hyperintensities (WMH) of presumed vascular origin, also referred to as
leukoaraiosis, are a very common finding on brain magnetic resonance imaging (MRI) or …

Vascular cognitive impairment defines alterations in cognition, ranging from subtle deficits to
full-blown dementia, attributable to cerebrovascular causes. Often coexisting with …

Objectives To review the evidence for an association of white matter hyperintensities with
risk of stroke, cognitive decline, dementia, and death. Design Systematic review and meta …

This review focuses on mechanisms and emerging concepts that drive the science of stroke
in a therapeutic direction. Once considered exclusively a disorder of blood vessels, growing …

Senescence is a leading cause of mortality, disability, and non‐communicable chronic
diseases in older adults. Mounting evidence indicates that the presence of cardiovascular …

WR Brown and CR Thore (2011) Neuropathology and Applied Neurobiology37, 56–74
Cerebral microvascular pathology in ageing and neurodegeneration This review of age …

The brain is highly dependent on an adequate delivery of oxygen and glucose from the
circulation, and cerebral blood flow (CBF) reductions impair neuronal function and, if …