Extracellular vesicles (EVs) are nano-sized, membranous structures secreted into the
extracellular space. They exhibit diverse sizes, contents, and surface markers and are …

Extracellular vesicles (EVs) are lipid‐bilayer membrane structures secreted by most cell
types. EVs act as messengers via the horizontal transfer of lipids, proteins, and nucleic …

Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …

Extracellular vesicles are highly transmissible and play critical roles in the propagation of tau
pathology, although the underlying mechanism remains elusive. Here, for the first time, we …

Background Recent studies suggest that microglia contribute to tau pathology progression in
Alzheimer's disease. Amyloid plaque accumulation transforms microglia, the primary innate …

Amyloid plaques contain many proteins in addition to beta amyloid (Aβ). Previous studies
examining plaque-associated proteins have shown these additional proteins are important; …

Neuron-derived extracellular vesicles (NDEVs) are potential biomarkers of neurological
diseases although their reliable molecular target is not well established. Here, we …

In neurodegenerative diseases, extracellular vesicles (EVs) transfer pathogenic molecules
and are consequently involved in disease progression. We have investigated the proteomic …

Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical
applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies …

Abstract Alzheimer's disease (AD), manifested by memory loss and a decline in cognitive
functions, is the most prevalent neurodegenerative disease accounting for 60–80% of …