The achievements of cell-based therapeutics have galvanized efforts to bring cell therapies
to the market. To address the demands of the clinical and eventual commercial-scale …

Human mesenchymal stem/stromal cells (hMSCs) present a key therapeutic cellular
intervention for use in cell and gene therapy (CGT) applications due to their …

The application of cell-based therapeutics requires development of refined and scalable
culture processes. Stirred tank bioreactors facilitate growth of human mesenchymal stromal …

Human induced pluripotent stem cells (hiPSC) are attractive tools for drug screening and
disease modeling and promising candidates for cell therapy applications. However, to …

Due to their unique features, mesenchymal stem/stromal cells (MSC) have been exploited in
clinical settings as therapeutic candidates for the treatment of a variety of diseases …

Industry 4.0 foresees a digital transformation of manufacturing resulting in smart factories
and supply chains. At the heart of the concept lies the vision of interconnected materials …

Particles in biopharmaceutical formulations remain a hot topic in drug product development.
With new product classes emerging it is crucial to discriminate particulate active …

To deliver the required cell numbers and doses to therapy, scaling-up production and
purification processes (at least to the liter-scale) while maintaining cells' characteristics is …

During the development of intranasal drug delivery systems for local/systemic effect or brain
targeting, it is necessary to assess its cytotoxicity and drug transport through nasal …

Anchorage‐dependent cell cultures are used for the production of viruses, viral vectors, and
vaccines, as well as for various cell therapies and tissue engineering applications. Most of …