Cells differentiate and progress through development guided by a dynamic chromatin
landscape that mediates gene expression programmes. During development, mammalian …

Our knowledge of pluripotent stem cell (PSC) biology has advanced to the point where we
now can generate most cells of the human body in the laboratory. PSC-derived …

Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …

Myocardial infarction is a leading cause of death worldwide. Although advances have been
made in acute treatment, an incomplete understanding of remodelling processes has limited …

Aims Deregulation of epigenetic processes and aberrant gene expression are important
mechanisms in heart failure. Here we studied the potential relevance of m6A RNA …

RNA m6A modification is the most widely distributed RNA methylation and is closely related
to various pathophysiological processes. Although the benefit of regular exercise on the …

The hallmark of most cardiac diseases is the progressive loss of cardiomyocytes. In the
perinatal period, cardiomyocytes still proliferate, and the heart shows the capacity to …

Cardiac injury and dysfunction occur in COVID-19 patients and increase the risk of mortality.
Causes are ill defined but could be through direct cardiac infection and/or inflammation …

Background Cardiovascular disease (CVD) is the leading cause of death worldwide and
considered one of the most environmentally driven diseases. The role of DNA methylation in …

Numerous epidemiological and animal studies disclosed that birth weight is inversely
associated with the incidence of the lifestyle-related disorders in adult life, such as …