Neuroendocrine mechanisms in the links between early life stress, affect, and youth substance use: a conceptual model for the study of sex and gender differences
Early life stress (ELS) is defined as an acute or chronic stressor that negatively impacts a
child's development. ELS is associated with substance use and mental health problems …
child's development. ELS is associated with substance use and mental health problems …
Corticotropin‐releasing factor signaling and its potential role in the prefrontal cortex‐dependent regulation of anxiety
X Yang, F Geng - Journal of Neuroscience Research, 2023 - Wiley Online Library
A large body of literature has highlighted the significance of the corticotropin‐releasing
factor (CRF) system in the regulation of neuropsychiatric diseases. Anxiety disorders are …
factor (CRF) system in the regulation of neuropsychiatric diseases. Anxiety disorders are …
Sex differences in ethanol consumption and drinking despite negative consequences following adolescent social isolation stress in male and female rats
BD McElroy, C Li, NS McCloskey, LG Kirby - Physiology & Behavior, 2023 - Elsevier
Alcohol use disorder (AUD) is a debilitating psychiatric disorder characterized by drinking
despite negative social and biological consequences. AUDs make up 71% of substance use …
despite negative social and biological consequences. AUDs make up 71% of substance use …
Sex differences in corticotropin releasing factor peptide regulation of inhibitory control and excitability in central amygdala corticotropin releasing factor receptor 1 …
AE Agoglia, J Tella, MA Herman - Neuropharmacology, 2020 - Elsevier
The central amygdala (CeA) is a critical regulator of emotional behavior that has been
implicated in psychiatric illnesses, including anxiety disorders and addiction. The CeA …
implicated in psychiatric illnesses, including anxiety disorders and addiction. The CeA …
Stress-enhanced ethanol drinking does not increase sensitivity to the effects of a CRF-R1 antagonist on ethanol intake in male and female mice
MA Nipper, ML Helms, DA Finn, AE Ryabinin - Alcohol, 2024 - Elsevier
Research confirms that stress is associated with alcohol drinking and relapse in males and
females and that there are sex differences in the alcohol-related adaptations of stress …
females and that there are sex differences in the alcohol-related adaptations of stress …
Scoping review on environmental enrichment: Are critical periods and sex differences adequately studied?
A Torres-Reveron, D Dow-Edwards - Pharmacology Biochemistry and …, 2022 - Elsevier
Background Decades of research have shown the robust behavioral, structural, and
molecular effects of environmental enrichment (EE) which predominantly improves …
molecular effects of environmental enrichment (EE) which predominantly improves …
Sex‐specific plasticity in CRF regulation of inhibitory control in central amygdala CRF1 neurons after chronic voluntary alcohol drinking
Despite strong preclinical evidence for the ability of corticotropin releasing factor 1 (CRF1)
antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated …
antagonists to regulate alcohol consumption, clinical trials have not yet demonstrated …
[HTML][HTML] Roles of corticotropin-releasing factor signaling in the lateral habenula in anxiety-like and alcohol drinking behaviors in male rats
Corticotropin-releasing factor (CRF) signaling in the mesocorticolimbic system is known to
modulate anxiety-like behavior and alcohol consumption, behaviors that also have been …
modulate anxiety-like behavior and alcohol consumption, behaviors that also have been …
Factors of sex and age dictate the regulation of GABAergic activity by corticotropin-releasing factor receptor 1 in the medial sub-nucleus of the central amygdala
Adolescents are phenotypically characterized with hyper-sensitivity to stress and
inappropriate response to stress-inducing events. Despite behavioral distinctions from …
inappropriate response to stress-inducing events. Despite behavioral distinctions from …
[HTML][HTML] Emerging pharmacological targets for alcohol use disorder
DF Brockway, NA Crowley - Alcohol, 2024 - Elsevier
ABSTRACT Alcohol Use Disorder (AUD) remains a challenging condition with limited
effective treatment options; however new technology in drug delivery and advancements in …
effective treatment options; however new technology in drug delivery and advancements in …