Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …

Osteocytes, former osteoblasts encapsulated by mineralized bone matrix, are far from being
passive and metabolically inactive bone cells. Instead, osteocytes are multifunctional and …

A decline in bone mass leading to an increased fracture risk is a common feature of age-
related bone changes. The mechanisms underlying bone senescence are very complex and …

Disuse and aging are known risk factors associated with low bone mass and quality
deterioration, resulting in increased fracture risk. Indeed, current and emerging evidence …

Abstract Purpose of Review The goal of this review is to provide an overview of the impact
and underlying mechanism of oxidative stress on connexin channel function, and their roles …

Abstract Purpose of Review Osteocytes are considered to be the cells responsible for
mastering the remodeling process that follows the exposure to unloading conditions. Given …

The skeleton adapts to mechanical loading to promote bone formation and remodeling.
While most bone cells are involved in mechanosensing, it is well accepted that osteocytes …

Osteoporosis and sarcopenia (termed “Osteosarcopenia”), the twin-aging diseases, are
major contributors to reduced bone mass and muscle weakness in the elderly population …

Osteocytes are the main sensitive cells in bone remodeling due to their potent functional cell
processes from the mineralized bone matrix to the bone surface and the bone marrow …

Vertebrate sexual dimorphism is ascribed to the presence of testes or ovaries, and, hence, to
the secretion of gonad-specific hormones. However, mounting evidence indicates that sex …