Huntington's disease (HD) is a neurodegenerative disorder that leads to progressive
neuronal loss, provoking impaired motor control, cognitive decline, and dementia. So far, HD …

Yeast models of neurodegenerative diseases associated with protein misfolding and protein
aggregation have given unique insights into the underlying genetic and cellular …

Heat shock proteins are involved in the response to stress including activation of the
immune response. Elevated circulating heat shock proteins are associated with …

The yeast Saccharomyces cerevisiae has been used to develop a wide range of highly
tractable living models of the major human neurodegenerative diseases. Yet even though …

Glutamine-rich tracts, also known as polyQ domains, have received a great deal of attention
for their role in multiple neurodegenerative diseases, including Huntington's disease (HD) …

Many neurodegenerative disorders display protein aggregation as a hallmark, Huntingtin
and TDP-43 aggregates being characteristic of Huntington disease and amyotrophic lateral …

Dictyostelium discoideum, the model organism for the evolutionary supergroup of
Amoebozoa, is a social amoeba that, upon starvation, undergoes transition from a …

Huntingtin (Htt) is a multi-function protein of the brain. Normal Htt shows a common alpha-
helical structure but conformational changes in the form with beta strands are the principal …

N-terminal mutant huntingtin (mHTT) fragments with pathogenic polyglutamine (polyQ) tracts
spontaneously form stable, amyloidogenic protein aggregates with a fibrillar morphology …

Protein misfolding characterizes most neurodegenerative diseases. Protein misfolding is the
conversion of specific proteins from their normal, often soluble, and native three-dimensional …