Background Mechanisms of airway repair are poorly understood. It has been proposed that,
following injury, progenitor populations such as club cells (Clara) become undifferentiated …

Background Clara cells are the epithelial progenitor cell of the small airways, a location
known to be important in many lung disorders. Although migration of alveolar type II and …

A new galactose-specific lectin was purified from seeds of a Caesalpinoideae plant,
Bauhinia variegata, by affinity chromatography on lactose-agarose. Protein extracts …

This study aimed to identify and specify the glycotypes of cell populations in normal human
lung including types I and II pneumocytes, alveolar macrophages and mast cells, and also in …

The overall pulmonary disposition of various fluorescent probes was viewed by confocal
imaging following intratracheal delivery in the rat in vivo. The green fluorescent dyes …

Few studies have directly compared the efficiencies of gene delivery methods that target
normal lung cells versus lung tumor cells. We report the first study directly comparing the …

Mammalian lung development is a complex process that is partially accomplished during the
postnatal period. Surface carbohydrates are crucial in many biological and pathological …

p21Waf1/Cip1 plays central roles in proliferation, differentiation, and apoptosis. Alterations
in the expression and subcellular localisation of p21 occur during several lung diseases but …

The A/J mouse strain is used in lung cancer studies. To enable mechanistic investigations
the isolation and cultivation of alveolar epithelial cells (AECs) is desirable. Based on four …

Background The p53 oncosuppressor protein is a critical mediator of the response to injury
in mammalian cells and is mutationally inactivated in the majority of lung malignancies. In …