The indole scaffold is one of the most widespread heterocycles in the naturally occurring
and synthetic bioactive compounds including anticancer agents. Due to its biodiversity and …

Multidrug resistance (MDR) is a serious problem that hampers the success of cancer
pharmacotherapy. A common mechanism is the overexpression of ATP-binding cassette …

Podophyllin-containing materials have been used as folk medicines for centuries. In the
1950s, scientists began a search to identify a more effective podophyllotoxin derivative …

Microtubules are a protein which is made of α-and β-heterodimer. It is one of the main
components of the cell which play a vital role in cell division especially in G2/M-phase. It …

▪ Abstract The eucaryotic cell cycle is regulated by the periodic synthesis and destruction of
cyclins that associate with and activate cyclin-dependent kinases. Cyclin-dependent kinase …

Ru (II) dyads derived from organic units that impart low-lying 3 IL excited states combine the
most attractive features of organic photosensitizers with those of coordination complexes …

Topoisomerase II is a ubiquitous enzyme that is essential for the survival of all eukaryotic
organisms and plays critical roles in virtually every aspect of DNA metabolism. The enzyme …

Although the one-dimensional sequence of DNA determines the genetic constitution of an
organism, topological relationships within the double helix modulate virtually every …

The major established cause of acute myeloid leukemia (AML) in the young is cancer
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de …

Genistein—a soy derived isullavone has recently attracted much attention of the medical
scientific community. This compound was found to be a potent agent in both prophylaxis and …