[HTML][HTML] Past, present and future of therapeutic strategies against amyloid-β peptides in Alzheimer's disease: A systematic review

D Jeremic, L Jiménez-Díaz, JD Navarro-López - Ageing research reviews, 2021 - Elsevier
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Hearing loss and cognition: what we know and where we need to go

DS Powell, ES Oh, NS Reed, FR Lin… - Frontiers in aging …, 2022 - frontiersin.org
Although a causal association remains to be determined, epidemiologic evidence suggests
an association between hearing loss and increased risk of dementia. If we determine the …

[HTML][HTML] Identifying health conditions associated with Alzheimer's disease up to 15 years before diagnosis: an agnostic study of French and British health records

T Nedelec, B Couvy-Duchesne, F Monnet… - The Lancet Digital …, 2022 - thelancet.com
Background The identification of modifiable risk factors for Alzheimer's disease is paramount
for early prevention and the targeting of new interventions. We aimed to assess the …

Hearing impairment and cognition in an aging world

DS Powell, ES Oh, FR Lin, JA Deal - … of the Association for Research in …, 2021 - Springer
With the increasing number of older adults around the world, the overall number of dementia
cases is expected to rise dramatically in the next 40 years. In 2020, nearly 6 million …

The impact and causal directions for the associations between diagnosis of ADHD, socioeconomic status, and intelligence by use of a bi-directional two-sample …

M Michaëlsson, S Yuan, H Melhus, JA Baron, L Byberg… - BMC medicine, 2022 - Springer
Background Previous studies have reported associations between attention-
deficit/hyperactivity disorder (ADHD) and lower socioeconomic status and intelligence. We …

Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and adiposity

GD Carrasquilla, M García-Ureña, T Fall, TIA Sørensen… - Elife, 2022 - elifesciences.org
Physical inactivity and increased sedentary time are associated with excess weight gain in
observational studies. However, some longitudinal studies indicate reverse causality where …

Genome-wide association meta-analysis identifies 29 new acne susceptibility loci

BL Mitchell, JR Saklatvala, N Dand… - Nature …, 2022 - nature.com
Acne vulgaris is a highly heritable skin disorder that primarily impacts facial skin. Severely
inflamed lesions may leave permanent scars that have been associated with long-term …

Variability in cochlear implantation outcomes in a large German cohort with a genetic etiology of hearing loss

A Tropitzsch, T Schade-Mann, P Gamerdinger… - Ear and …, 2023 - journals.lww.com
Objectives: The variability in outcomes of cochlear implantation is largely unexplained, and
clinical factors are not sufficient for predicting performance. Genetic factors have been …

Dementia prevention in clinical practice

K Niotis, K Akiyoshi, C Carlton… - Seminars in …, 2022 - thieme-connect.com
Over 55 million people globally are living with dementia and, by 2050, this number is
projected to increase to 131 million. This poses immeasurable challenges for patients and …

Effect of hearing aids on cognitive functions in middle-aged and older adults with hearing loss: a systematic review and meta-analysis

Z Yang, J Ni, Y Teng, M Su, M Wei, T Li… - Frontiers in Aging …, 2022 - frontiersin.org
Objective The study aimed to examine the effects of hearing aids on cognitive function in
middle-aged and older adults with hearing loss. Data sources and study selection PubMed …