The acute respiratory distress syndrome (ARDS) is a common cause of respiratory failure in
critically ill patients and is defined by the acute onset of noncardiogenic pulmonary oedema …

Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart
disease and stroke in humans. It is characterized by intimal plaques and cholesterol …

Uncontrolled inflammation is a leading cause of many clinically relevant diseases. Current
therapeutic strategies focus mainly on immunosuppression rather than on the mechanisms …

Abstract Heme oxygenase-1 (HO-1) is considered to be the main protein in diseases arising
as a result of oxidative and inflammatory insults. Tremendous research has been carried out …

Abstract Significance: The hemoglobin (Hb) scavenger receptor, CD163, is a macrophage-
specific protein and the upregulated expression of this receptor is one of the major changes …

Rationale: Growing evidence indicates that intracellular reactive oxygen species (ROS)
accumulation is a critical factor in the development of osteoporosis by triggering osteoclast …

Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-limiting enzyme of
heme degradation. Induction of HO-1 protects against the cytotoxicity of oxidative stress and …

Over the last decade, studies have unraveled many aspects of endogenous production and
physiological functions of carbon monoxide (CO). The majority of endogenous CO is …

Severe hemolysis or myolysis occurring during pathological states, such as sickle cell
disease, ischemia reperfusion, and malaria results in high levels of free heme, causing …

Glutathione (GSH) and bilirubin are prominent endogenous antioxidant cytoprotectants.
Despite tissue levels that are thousands of times lower than GSH, bilirubin is effective …