This Review examines recent developments in late transition metal-catalyzed
hydroamination and-amidation reactions. A hydroamination is a reaction in which an N− H …

Imidazopyridine is one of the important fused bicyclic 5–6 heterocycles and it is recognized
as a “drug prejudice” scaffold due to its wide range of applications in medicinal chemistry …

In recent years, the transition-metal catalyzed three-component coupling of an aldehyde, an
alkyne and an amine, commonly called A3-coupling, has been established as a convenient …

This review presents a comprehensive overview on selected synthetic routes towards
commercial drug compounds as published in both journal and patent literature. Owing to the …

Heterocycles are an extraordinarily important class of compounds, making up more than half
of all known organic compounds. Heterocycles are present in a wide variety of drugs, most …

Multicomponent reactions are a valuable tool for the synthesis of functional π-electron
systems. Two different approaches can be taken into account for accessing the target …

Modern drug discovery is contingent on identifying lead compounds and rapidly
synthesizing analogues. The use of a common pharmacophore to direct multiple and …

Particular success has been achieved in the synthesis of new products and in processes
since the twelve principles of “green chemistry” were formulated in the 1990s. These …

The efficiency of a chemical synthesis can be nowadays measured, not only by parameters
like selectivity and overall yield, but also by its raw material, time, human resources and …

A short and efficient route to a broad range of imidazo [1, 2-a] pyridines from 2-
aminopyridines and acetophenones is achieved by a tandem, one-pot process starting with …