It has become increasingly clear that a subset of T cells which persist at diverse infection
sites, known as tissue-resident memory T cells (T RM), can mediate efficacious protective …

Background Resident memory T cells have emerged as key players in the immune response
generated against a number of pathogens. Their ability to take residence in non-lymphoid …

Introduction: With the increasing number of vaccines and vaccine-preventable diseases, the
pressure to generate multi-valent and multi-pathogen vaccines grows. Combining individual …

The extracellular virion (EV) form of Orthopoxviruses is required for cell-to-cell spread and
pathogenesis, and is the target of neutralizing antibodies in the protective immune response …

We report here the complete genome sequence of raccoonpox virus (RCNV), a naturally
occurring North American poxvirus. This is the first such North American sequence to the …

Highlights•VacV skin infection generates highly functional effector and memory CD8+ T
cells.•Both direct and cross-presentation of antigen activates naïve CD8+ T cells.•Effector …

While both pNGVL4a-Sig/E7 (detox)/HSP70 DNA vaccine and TA-HPV recombinant
vaccinia viral vector-based vaccines have elicited HPV-specific CD8+ T cell responses in …

All known orthopoxviruses, including ectromelia virus (ECTV), contain a gene in the E3L
family. The protein product of this gene, E3, is a double-stranded RNA-binding protein. It can …

Poxviruses cause many diseases in humans and animals worldwide, and there is a need for
vaccines with improved safety and good efficacy. In addition, poxvirus vectors are widely …

Pancreatic cancer is the 5th leading cause of cancer deaths, and there are no effective
treatments. We developed a poxvirus platform vaccine with improved immunogenicity and …