The role of short-chain fatty acids in intestinal barrier function, inflammation, oxidative stress, and colonic carcinogenesis
P Liu, Y Wang, G Yang, Q Zhang, L Meng, Y Xin… - Pharmacological …, 2021 - Elsevier
Short-chain fatty acids (SCFAs), mainly including acetate, propionate, and butyrate, are
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …
metabolites produced during the bacterial fermentation of dietary fiber in the intestinal tract …
The metabolic signature of macrophage responses
Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …
functions in homeostatic and immune responses. The broad spectrum of macrophage …
Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma
Z Yang, C Yan, J Ma, P Peng, X Ren, S Cai, X Shen… - Nature …, 2023 - nature.com
Enhanced glycolysis and accumulation of lactate is a common feature in various types of
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
cancer. Intracellular lactate drives a recently described type of posttranslational modification …
Metabolic functions of the tumor suppressor p53: Implications in normal physiology, metabolic disorders, and cancer
Background The TP53 gene is one of the most commonly inactivated tumor suppressors in
human cancers. p53 functions during cancer progression have been linked to a variety of …
human cancers. p53 functions during cancer progression have been linked to a variety of …
[PDF][PDF] An acetylation switch of the NLRP3 inflammasome regulates aging-associated chronic inflammation and insulin resistance
It is well documented that the rate of aging can be slowed, but it remains unclear to which
extent aging-associated conditions can be reversed. How the interface of immunity and …
extent aging-associated conditions can be reversed. How the interface of immunity and …
Escherichia coli as a host for metabolic engineering
Over the past century, Escherichia coli has become one of the best studied organisms on
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
earth. Features such as genetic tractability, favorable growth conditions, well characterized …
[PDF][PDF] Oligodendrocytes enhance axonal energy metabolism by deacetylation of mitochondrial proteins through transcellular delivery of SIRT2
Neurons require mechanisms to maintain ATP homeostasis in axons, which are highly
vulnerable to bioenergetic failure. Here, we elucidate a transcellular signaling mechanism …
vulnerable to bioenergetic failure. Here, we elucidate a transcellular signaling mechanism …
The growing landscape of lysine acetylation links metabolism and cell signalling
Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …
Acetyl-CoA and the regulation of metabolism: mechanisms and consequences
L Shi, BP Tu - Current opinion in cell biology, 2015 - Elsevier
Acetyl-CoA represents a key node in metabolism due to its intersection with many metabolic
pathways and transformations. Emerging evidence reveals that cells monitor the levels of …
pathways and transformations. Emerging evidence reveals that cells monitor the levels of …
Histone deacetylase 6 structure and molecular basis of catalysis and inhibition
Y Hai, DW Christianson - Nature chemical biology, 2016 - nature.com
Abstract Histone deacetylase 6 (HDAC6) is a critical target for drug design because of its
role in oncogenic transformation and cancer metastasis, and is unique among all histone …
role in oncogenic transformation and cancer metastasis, and is unique among all histone …