The gut microbiota has a critical role in the maintenance of immune homeostasis. Alterations
in the intestinal microbiota and gut microbiota-derived metabolites have been recognized in …

BACKGROUND As the world population ages, chronic diseases such as diabetes,
cardiovascular disease, cancer, and neurodegeneration become ever more prevalent …

Obesity is associated with impaired intestinal barrier function and dysbiosis of the gut
microbiota. Spermidine, a polyamine that acts as an autophagy inducer, has important …

The genus Roseburia consists of obligate Gram-positive anaerobic bacteria that are slightly
curved, rod-shaped and motile by means of multiple subterminal flagella. It includes five …

The composition and activity of the gut microbiota codevelop with the host from birth and is
subject to a complex interplay that depends on the host genome, nutrition, and life-style. The …

The microbiota of gut is the community of microbes living in an individual's gastrointestinal
tract. Several bacterial genera and species act in a concerted manner to establish metabolic …

The gastrointestinal tract is a complex ecosystem that contains a large number of
microorganisms with different metabolic capacities. Modulation of the gut microbiome can …

Background The cross-talk between the host and its microbiota plays a key role in the
promotion of health. The production of metabolites such as polyamines by intestinal-resident …

The polyamines putrescine, spermidine, and spermine are widely distributed polycationic
compounds essential for cellular functions. Intracellular polyamine pools are tightly …

Spermidine is a natural polyamine that stimulates cytoprotective macroautophagy/
autophagy. External supplementation of spermidine extends lifespan and health span …