[HTML][HTML] Antiviral activity of natural phenolic compounds in complex at an allosteric site of SARS-CoV-2 papain-like protease
V Srinivasan, H Brognaro, PR Prabhu… - Communications …, 2022 - nature.com
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
cysteine-protease activity, facilitating cleavage of the viral polypeptide chain, PLpro has the …
[HTML][HTML] Some common deleterious mutations are shared in SARS-CoV-2 genomes from deceased COVID-19 patients across continents
The identification of deleterious mutations in different variants of SARS-CoV-2 and their
roles in the morbidity of COVID-19 patients has yet to be thoroughly investigated. To unravel …
roles in the morbidity of COVID-19 patients has yet to be thoroughly investigated. To unravel …
Differential mutation profile of SARS-CoV-2 proteins across deceased and asymptomatic patients
Abstract Background The SARS-CoV-2 infection has spread at an alarming rate with many
places showing multiple peaks in incidence. Present study analyzes a total of 332 SARS …
places showing multiple peaks in incidence. Present study analyzes a total of 332 SARS …
Genetic determinants of SARS‐CoV‐2 and the clinical outcome of COVID‐19 in Southern Bangladesh
Background The coronavirus disease 2019 (COVID‐19) pandemic has had a severe impact
on population health. The genetic determinants of severe acute respiratory syndrome …
on population health. The genetic determinants of severe acute respiratory syndrome …
SARS-CoV-2 papain-like protease PLpro in complex with natural compounds reveal allosteric sites for antiviral drug design
V Srinivasan, H Brognaro, PR Prabhu, EE de Souza… - Biorxiv, 2021 - biorxiv.org
Abstract SARS-CoV-2 papain-like protease (PLpro) covers multiple functions. Beside the
cysteine-protease activity, PLpro has the additional and vital function of removing ubiquitin …
cysteine-protease activity, PLpro has the additional and vital function of removing ubiquitin …
[HTML][HTML] Analyzing the interaction of human ACE2 and RBD of spike protein of SARS-CoV-2 in perspective of Omicron variant
The newly identified Omicron (B. 1.1. 529) variant of Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2) has steered concerns across the world due to the possession …
Coronavirus 2 (SARS-CoV-2) has steered concerns across the world due to the possession …
Codon usage patterns of the eleven SARS-CoV-2 variants with reference to the Wuhan sequence
SARS-CoV-2 has been one of the most challenging public health concerns in recent times.
Though the incidences have slowed down there is still lot to be elucidated about the …
Though the incidences have slowed down there is still lot to be elucidated about the …
[HTML][HTML] Decoding the genetics of viral evolution
There are multiple facets to successfully tackling the menace of viral diseases. These
include monitoring the sequence variations and emergence of new viruses/variants which …
include monitoring the sequence variations and emergence of new viruses/variants which …