Pre-eclampsia is a life-threatening disease of pregnancy unique to humans and a leading
cause of maternal and neonatal morbidity and mortality. Women who survive pre-eclampsia …

Pre-eclampsia is a multisystem pregnancy disorder characterised by variable degrees of
placental malperfusion, with release of soluble factors into the circulation. These factors …

It has been widely known that oxidative stress disrupts the balance between reactive oxygen
species (ROS) and the antioxidant system in the body. During pregnancy, the physiological …

Early-onset preeclampsia has been linked to poor placentation and fetal growth restriction,
whereas late-onset preeclampsia was suggested to result from maternal factors. We have …

Physiological transformation with remodeling of the uteroplacental spiral arteries is key to a
successful placentation and normal placental function. It is an intricate process that involves …

Abstract Cardiovascular disease complicates 1–4% of pregnancies—with a higher
prevalence when including hypertensive disorders—and is the leading cause of maternal …

Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …

Purpose of the Review. To highlight the role of oxidative stress in hypertensive disorders of
pregnancy (HDP) and metabolic disorders of pregnancy (gestational diabetes mellitus) …

Pre-eclampsia is characterized by new-onset hypertension and proteinuria at≥ 20 weeks of
gestation. In the absence of proteinuria, hypertension together with evidence of systemic …

The placenta is arguably the most important organ of the body, but paradoxically the most
poorly understood. During its transient existence, it performs actions that are later taken on …