Rho GTPases are a family of small G proteins that regulate a wide array of cellular
processes related to their key roles controlling the cytoskeleton. Cancer is a multistep …

The JAK/STAT3 signaling pathway plays an essential role in various types of cancers.
Activation of this pathway leads to increased tumorigenic and metastatic ability, the transition …

A hallmark of cancer cells includes a metabolic reprograming that provides energy, the
essential building blocks, and signaling required to maintain survival, rapid growth …

Next-generation sequencing technologies have greatly expanded our understanding of
cancer genetics. Antisense technology is an attractive platform with the potential to translate …

Weight loss is diagnostic of cachexia, a debilitating syndrome contributing mightily to
morbidity and mortality in cancer. Most research has probed mechanisms leading to muscle …

Hepatocellular carcinoma (HCC) is one of the most lethal malignancies, and is also the
fourth most common cancer worldwide with around 700,000 new cases each year …

STAT3 is constitutively activated in colon cancer but its contributions in cancer-initiating cells
have not been explored. In this study, we characterized STAT3 in aldehyde dehydrogenase …

Rho-associated kinase 2 (ROCK2) regulates the secretion of proinflammatory cytokines and
the development of autoimmunity in mice. Data from a phase 1 clinical trial demonstrate that …

Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer.
Although the fundamental link between HPV infection and oncogenesis is established, the …

Aberrant placental angiogenesis is associated with fetal intrauterine growth restriction
(IUGR), but the mechanism underlying abnormal placental angiogenesis remains largely …